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Motion corrected DW...
Motion corrected DWI with integrated T2-mapping for simultaneous estimation of ADC, T2-relaxation and perfusion in prostate cancer
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- Skorpil, Mikael (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Department of Radiology, Uppsala University Hospital, Uppsala, Sweden,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.
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- Brynolfsson, Patrik (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.
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- Engström, M. (author)
- GE Healthcare, Appl Sci Lab, Uppsala, Sweden.
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- English.
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In: Magnetic Resonance Imaging. - : Elsevier. - 0730-725X .- 1873-5894. ; 39, s. 162-167
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Abstract
Subject headings
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- Objective: Multiparametric magnetic resonance imaging (MRI) and PI-RADS (Prostate Imaging - Reporting and Data System) has become the standard to determine a probability score for a lesion being a clinically significant prostate cancer. T2-weighted and diffusion-weighted imaging (DWI) are essential in PI-RADS, depending partly on visual assessment of signal intensity, while dynamic-contrast enhanced imaging is less important. To decrease inter-rater variability and further standardize image evaluation, complementary objective measures are in need. Methods: We here demonstrate a sequence enabling simultaneous quantification of apparent diffusion coefficient (ADC) and T2-relaxation, as well as calculation of the perfusion fraction f from low b-value intravoxel incoherent motion data. Expandable wait pulses were added to a FOCUS DW SE-EPI sequence, allowing the effective echo time to change at run time. To calculate both ADC and f, b-values 200 s/mm(2) and 600 s/mm(2) were chosen, and for T2-estimation 6 echo times between 64.9 ms and 114.9 ms were used. Results: Three patients with prostate cancer were examined and all had significantly decreased ADC and T2 values, while f was significantly increased in 2 of 3 tumors. T2 maps obtained in phantom measurements and in a healthy volunteer were compared to T2 maps from a SE sequence with consecutive scans, showing good agreement. In addition, a motion correction procedure was implemented to reduce the effects of prostate motion, which improved T2-estimation. Conclusions: This sequence could potentially enable more objective tumor grading, and decrease the inter-rater variability in the PI-RADS classification.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Keyword
- Prostate cancer
- Apparent diffusion coefficient
- Diffusion weighted imaging
- T2-relaxation
- Magnetic resonance imaging
- Perfusion
Publication and Content Type
- ref (subject category)
- art (subject category)
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