Lower cognitive performance among long-term type 1 diabetes survivors: A case-control study

Awad, AnnaDepartment of Public Health and Clinical Medicine, Sunderby Research Unit, Umeå University, Sweden. (author)

Lower cognitive performance among long-term type 1 diabetes survivors : A case-control study

OBJECTIVE: Patients with type 1 diabetes (T1D) have an increased risk of cognitive dysfunction. The cognitive decrement is believed to depend on macro- and microvascular complications and long disease duration. Some patients do not develop these complications, but still report cognitive symptoms. We examined if long-standing T1D without complications is associated with lower cognitive performance.METHODS: A group of patients (n=43) with long-standing T1D (>30years) without micro- or macro vascular complications was compared with a non-diabetic control group (n=86) on six cognitive tests which probed episodic memory, semantic memory, episodic short-term memory, visual attention and psychomotor speed. Each patient was matched with two controls regarding age, gender and education. A linear mixed effect model was used to analyze the data.RESULTS: The mean age was 57years and mean duration was 41years. Patients with diabetes had lower diastolic blood pressure but BMI, waist circumference, systolic blood pressure and smoking did not differ between groups. Patients had lower results than non-diabetic controls in episodic short-term memory (p<0.001) and also lower values on a test that mirrors visual attention and psychomotor speed (p=0.019).CONCLUSIONS: Long-standing T1D was associated with lower cognitive performance, regardless of other diabetes-related complications.

Lundqvist, RobertResearch and Innovation Unit, Norrbotten County Council, Luleå, Sweden.(Swepub:umu)laro0005 (author)
Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005 (author)
Sundström, AnnaUmeå universitet,Institutionen för psykologi,Enheten för demografi och åldrandeforskning (CEDAR),Centre of Demographic and Ageing Research (CEDAR), Umeå University, Sweden.(Swepub:umu)ansu0001 (author)
Eliasson, MatsUmeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Sunderby Research Unit, Umeå University, Sweden.(Swepub:umu)mael0021 (author)
Department of Public Health and Clinical Medicine, Sunderby Research Unit, Umeå University, Sweden.Research and Innovation Unit, Norrbotten County Council, Luleå, Sweden. (creator_code:org_t)

In:Journal of diabetes and its complications: Elsevier31:8, s. 1328-13311056-87271873-460X

By the author/editor: Awad, Anna; Lundqvist, Rober ...; Rolandsson, Olov; Sundström, Anna; Eliasson, Mats

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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