The impact of time to heart failure diagnosis on outcomes in patients tailored for heart failure treatment by use of natriuretic peptides. Results from the UPSTEP study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:DiVA.org:umu-137064" > The impact of time ...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Karlstrom, PatricCounty Hospital Ryhov, Sweden (author)

The impact of time to heart failure diagnosis on outcomes in patients tailored for heart failure treatment by use of natriuretic peptides. Results from the UPSTEP study

Article/chapterEnglish2017

Publisher, publication year, extent ...

ELSEVIER IRELAND LTD,2017
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-137064
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137064URI
https://doi.org/10.1016/j.ijcard.2017.02.054DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138904URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Funding Agencies|Regional Research Foundation in south-eastern Sweden [FORSS-3963, FORSS-5677, FORSS-F2004-223]; Regional Research Foundation in northern Sweden [33/2006, 20/2007]; Swedish Heart-Lung Foundation [2000596]; Biosite International and Infiniti Medical AB
Background: Heart failure (HF) is a life-threatening condition and optimal handling is necessary to reduce risk of therapy failure. The impact of the duration of HF diagnosis on HF outcome has not previously been examined. The objectives of this study were (I) to evaluate the impact of patient age on clinical outcomes, (II) to evaluate the impact of duration of the HF disease on outcomes, and (III) to evaluate the impact of age and HF duration on B-type Natriuretic Peptide (BNP) concentration in a population of HF patients. Methods and results: In the UPSTEP (Use of PeptideS in Tailoring hEart failure Project) study we retrospectively evaluated how age and HF duration affected HF outcome. HF duration was divided into < 1 year, 1-5 years and > 5 years. A multivariate Cox proportional hazard regression analysis showed that HF duration influenced outcome more than age, even when adjusted for comorbidities(< 1 year versus > 5 years: HR 1.65; 95% CI 1.28-2.14; P < 0.0002) on HF mortality and hospitalisations. The influence of age on BNP showed increased BNP as age increased. However, there was a significant effect on BNP concentration when comparing HF duration of less than one year to HF duration to more than five years, even when adjusted for age. Conclusions: Patients with longer HF duration had significantly worse outcome compared to those with short HF duration, even when adjusted for patient age and comorbidities. Age did not influence outcome but had an impact on BNP concentration; however, BNP concentration increased as HF duration increased.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
Heart failure
B-type Natriuretic Peptides
Age
Heart failure duration
Heart failure outcome

Added entries (persons, corporate bodies, meetings, titles ...)

Johansson, Peter,1962-Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)petjo71 (author)
Dahlström, UlfLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)ulfda85 (author)
Boman, KurtUmeå universitet,Medicin,Umeå University, Sweden(Swepub:umu)kubo0001 (author)
Alehagen, UrbanLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)urbal84 (author)
County Hospital Ryhov, SwedenAvdelningen för kardiovaskulär medicin (creator_code:org_t)

Related titles

In:International Journal of Cardiology: ELSEVIER IRELAND LTD236, s. 315-3200167-52731874-1754

Internet link

Find in a library

International Journal of Cardiology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Karlstrom, Patri ...; Johansson, Peter ...; Dahlström, Ulf; Boman, Kurt; Alehagen, Urban

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and General Practice

Articles in the publication: International Jo ...

By the university: Umeå University; Linköping University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se