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Predicting Islet Ce...
Predicting Islet Cell Autoimmunity and Type 1 Diabetes : An 8-Year TEDDY Study Progress Report
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- Krischer, Jeffrey P (författare)
- University of South Florida
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- Liu, Xiang (författare)
- University of South Florida
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- Vehik, Kendra (författare)
- University of South Florida
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visa fler...
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- Akolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Hagopian, William A (författare)
- Pacific Northwest Research Institute
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- Rewers, Marian J (författare)
- University of Colorado
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- She, Jin-Xiong (författare)
- Medical College of Georgia
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- Toppari, Jorma (författare)
- University of Turku,Turku University Hospital
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- Ziegler, Anette-G (författare)
- Technical University of Munich
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Agardh, Daniel (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Andrén Aronsson, Carin (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ask, Maria (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Bremer, Jenny (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ericson-Hallström, Emelie (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Björne Fors, Annika (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Fransson, Lina (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Gard, Thomas (creator_code:cre_t)
- Lund University,Lunds universitet,Trafik och väg,Institutionen för teknik och samhälle,Institutioner vid LTH,Lunds Tekniska Högskola,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Transport and Roads,Department of Technology and Society,Departments at LTH,Faculty of Engineering, LTH,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Bennet, Rasmus (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Hyberg, Susanne (creator_code:cre_t)
- Lund University
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- Jisser, Hanna (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Johansen, Fredrik (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Jónsdóttir, Berglind (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- JOVIC, SILVIJA (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Elding Larsson, Helena (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Lindström, Marielle (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Lundgren, Markus (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Månsson Martinez, Maria (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Markan, Maria (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Melin, Marie Jessica (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Mestan, Zeliha (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Nilsson, Caroline N (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Ottosson, Karin (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Rahmati, Kobra (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ramelius, Anita (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Salami, Falastin (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Sjöberg, Anette (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Sjöberg, Birgitta (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Törn, Carina (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Wallin, Anne (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Wimar, Åsa (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Åberg, Sofie (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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(creator_code:org_t)
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- 2019-04-09
- 2019
- Engelska 10 s.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 42:6, s. 1051-1060
- Relaterad länk:
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http://dx.doi.org/10...
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https://care.diabete...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Assessment of the predictive power of The Environmental Determinants of Diabetes in the Young (TEDDY)-identified risk factors for islet autoimmunity (IA), the type of autoantibody appearing first, and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS: A total of 7,777 children were followed from birth to a median of 9.1 years of age for the development of islet autoantibodies and progression to T1D. Time-dependent sensitivity, specificity, and receiver operating characteristic (ROC) curves were calculated to provide estimates of their individual and collective ability to predict IA and T1D.RESULTS: HLA genotype (DR3/4 vs. others) was the best predictor for IA (Youden's index J = 0.117) and single nucleotide polymorphism rs2476601, in PTPN22, was the best predictor for insulin autoantibodies (IAA) appearing first (IAA-first) (J = 0.123). For GAD autoantibodies (GADA)-first, weight at 1 year was the best predictor (J = 0.114). In a multivariate model, the area under the ROC curve (AUC) was 0.678 (95% CI 0.655, 0.701), 0.707 (95% CI 0.676, 0.739), and 0.686 (95% CI 0.651, 0.722) for IA, IAA-first, and GADA-first, respectively, at 6 years. The AUC of the prediction model for T1D at 3 years after the appearance of multiple autoantibodies reached 0.706 (95% CI 0.649, 0.762).CONCLUSIONS: Prediction modeling statistics are valuable tools, when applied in a time-until-event setting, to evaluate the ability of risk factors to discriminate between those who will and those who will not get disease. Although significantly associated with IA and T1D, the TEDDY risk factors individually contribute little to prediction. However, in combination, these factors increased IA and T1D prediction substantially.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Krischer, Jeffre ...
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Liu, Xiang
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Vehik, Kendra
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Akolkar, Beena
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Hagopian, Willia ...
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Rewers, Marian J
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visa fler...
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She, Jin-Xiong
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Toppari, Jorma
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Ziegler, Anette- ...
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Lernmark, Åke
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Agardh, Daniel
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Andrén Aronsson, ...
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Ask, Maria
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Bremer, Jenny
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Ericson-Hallströ ...
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Björne Fors, Ann ...
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Fransson, Lina
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Gard, Thomas
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Bennet, Rasmus
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Hyberg, Susanne
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Jisser, Hanna
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Johansen, Fredri ...
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Jónsdóttir, Berg ...
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JOVIC, SILVIJA
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Elding Larsson, ...
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Lindström, Marie ...
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Lundgren, Markus
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Månsson Martinez ...
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Markan, Maria
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Melin, Marie Jes ...
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Mestan, Zeliha
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Nilsson, Carolin ...
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Ottosson, Karin
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Rahmati, Kobra
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Ramelius, Anita
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Salami, Falastin
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Sjöberg, Anette
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Sjöberg, Birgitt ...
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Törn, Carina
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Wallin, Anne
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Wimar, Åsa
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Åberg, Sofie
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Diabetes Care
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Lunds universitet