Search: (WFRF:(Caporaso Neil)) srt2:(2017) >
Large-scale associa...
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
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- McKay, James D. (author)
- International Agency for Research on Cancer, World Health Organization
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- Hung, Rayjean J. (author)
- University of Toronto
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- Han, Younghun (author)
- Dartmouth College
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show more...
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- Zong, Xuchen (author)
- University of Toronto
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- Carreras-Torres, Robert (author)
- International Agency for Research on Cancer, World Health Organization
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- Christiani, David C. (author)
- Harvard Medical School,Dartmouth College
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- Caporaso, Neil E. (author)
- National Institutes of Health, United States
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, World Health Organization
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- Xiao, Xiangjun (author)
- Karolinska Institutet
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- Li, Yafang (author)
- Dartmouth College
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- Byun, Jinyoung (author)
- Dartmouth College
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- Dunning, Alison (author)
- University of Cambridge
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- Pooley, Karen A. (author)
- University of Cambridge
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Qian, David C. (author)
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- Ji, Xuemei (author)
- Dartmouth College
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- Liu, Geoffrey (author)
- University of Toronto
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- Timofeeva, Maria N. (author)
- International Agency for Research on Cancer, World Health Organization
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- Bojesen, Stig E. (author)
- Copenhagen University Hospital
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- Wu, Xifeng (author)
- University of Texas
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- Le Marchand, Loic (author)
- University of Hawaii Cancer Center
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- Albanes, Demetrios (author)
- National Institutes of Health, United States
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- Bickeböller, Heike (author)
- University of Göttingen
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- Aldrich, Melinda C. (author)
- Vanderbilt University Medical Center
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- Bush, William S. (author)
- Case Western Reserve University
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- Tardon, Adonina (author)
- University of Oviedo
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- Rennert, Gad (author)
- Carmel Medical Center
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- Teare, M. Dawn (author)
- University of Sheffield
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- Field, John K. (author)
- University of Liverpool
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- Kiemeney, Lambertus A. (author)
- Radboud University Medical Center
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- Lazarus, Philip (author)
- Washington State University
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- Haugen, Aage (author)
- National Institute of Occupational Health, Norway
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- Lam, Stephen (author)
- British Columbia Cancer Agency
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- Schabath, Matthew B. (author)
- H. Lee Moffitt Cancer Center & Research Institute
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- Andrew, Angeline S. (author)
- Dartmouth College
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- Shen, Hongbing (author)
- Nanjing Medical University
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- Hong, Yun-Chul (author)
- Seoul National University
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- Yuan, Jian-Min (author)
- University of Pittsburgh Cancer Institute
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- Bertazzi, Pier Alberto (author)
- University of Milan
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- Pesatori, Angela C. (author)
- University of Milan
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- Ye, Yuanqing (author)
- University of Texas
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- Diao, Nancy (author)
- Harvard T.H. Chan School of Public Health
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- Su, Li (author)
- Harvard T.H. Chan School of Public Health
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- Zhang, Ruyang (author)
- Harvard T.H. Chan School of Public Health
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- Brhane, Yonathan (author)
- University of Toronto
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- Leighl, Natasha (author)
- Princess Margaret Hospital University of Toronto
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- Johansen, Jakob S. (author)
- Copenhagen University Hospital
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Mellemgaard, Anders (author)
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Saliba, Walid (author)
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Haiman, Christopher A. (author)
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Wilkens, Lynne R. (author)
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Fernandez-Somoano, Ana (author)
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Fernandez-Tardon, Guillermo (author)
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van der Heijden, Henricus F. M. (author)
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Kim, Jin Hee (author)
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Dai, Juncheng (author)
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Hu, Zhibin (author)
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Davies, Michael P. A. (author)
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Marcus, Michael W. (author)
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- Brunnström, Hans (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Muller, David C. (author)
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Overvad, Kim (author)
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Trichopoulou, Antonia (author)
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Tumino, Rosario (author)
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Doherty, Jennifer A. (author)
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Barnett, Matt P. (author)
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Chen, Chu (author)
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Goodman, Gary E. (author)
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Cox, Angela (author)
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Taylor, Fiona (author)
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Woll, Penella (author)
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Brüske, Irene (author)
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Wichmann, H-Erich (author)
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Manz, Judith (author)
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Muley, Thomas R. (author)
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Risch, Angela (author)
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Rosenberger, Albert (author)
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- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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- Johansson, Mikael (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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Shepherd, Frances A. (author)
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Tsao, Ming-Sound (author)
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Arnold, Susanne M. (author)
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Haura, Eric B. (author)
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Bolca, Ciprian (author)
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Holcatova, Ivana (author)
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Janout, Vladimir (author)
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Kontic, Milica (author)
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Lissowska, Jolanta (author)
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Mukeria, Anush (author)
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Ognjanovic, Simona (author)
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Orlowski, Tadeusz M. (author)
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Scelo, Ghislaine (author)
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Swiatkowska, Beata (author)
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Zaridze, David (author)
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Bakke, Per (author)
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Skaug, Vidar (author)
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Zienolddiny, Shanbeh (author)
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Duell, Eric J. (author)
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Butler, Lesley M. (author)
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Koh, Woon-Puay (author)
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Gao, Yu-Tang (author)
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Houlston, Richard S. (author)
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McLaughlin, John (author)
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Stevens, Victoria L. (author)
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Joubert, Philippe (author)
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Lamontagne, Maxime (author)
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Nickle, David C. (author)
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Obeidat, Ma'en (author)
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Timens, Wim (author)
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Zhu, Bin (author)
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- Song, Lei (author)
- National Institutes of Health, United States
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Kachuri, Linda (author)
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Artigas, Maria Soler (author)
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Tobin, Martin D. (author)
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Wain, Louise V. (author)
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Rafnar, Thorunn (author)
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Thorgeirsson, Thorgeir E. (author)
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Reginsson, Gunnar W. (author)
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Stefansson, Kari (author)
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Hancock, Dana B. (author)
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Bierut, Laura J. (author)
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Spitz, Margaret R. (author)
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Gaddis, Nathan C. (author)
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Lutz, Sharon M. (author)
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Gu, Fangyi (author)
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Johnson, Eric O. (author)
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Kamal, Ahsan (author)
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Pikielny, Claudio (author)
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Zhu, Dakai (author)
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Lindström, Sara (author)
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Jiang, Xia (author)
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Tyndale, Rachel F. (author)
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Chenevix-Trench, Georgia (author)
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Beesley, Jonathan (author)
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Bossé, Yohan (author)
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Chanock, Stephen (author)
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Brennan, Paul (author)
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Landi, Maria Teresa (author)
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Amos, Christopher I. (author)
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(creator_code:org_t)
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- 2017-06-12
- 2017
- English.
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 49:7, s. 1126-1132
- Related links:
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https://europepmc.or...
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Genome-wide association studies
- Lung cancer
- Transcriptomics
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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McKay, James D.
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Hung, Rayjean J.
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Han, Younghun
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Zong, Xuchen
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Carreras-Torres, ...
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Christiani, Davi ...
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show more...
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Caporaso, Neil E ...
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Johansson, Matti ...
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Xiao, Xiangjun
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Li, Yafang
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Byun, Jinyoung
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Dunning, Alison
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Pooley, Karen A.
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Qian, David C.
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Ji, Xuemei
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Liu, Geoffrey
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Timofeeva, Maria ...
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Bojesen, Stig E.
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Wu, Xifeng
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Le Marchand, Loi ...
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Albanes, Demetri ...
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Bickeböller, Hei ...
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Aldrich, Melinda ...
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Bush, William S.
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Tardon, Adonina
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Rennert, Gad
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Teare, M. Dawn
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Field, John K.
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Kiemeney, Lamber ...
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Lazarus, Philip
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Haugen, Aage
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Lam, Stephen
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Schabath, Matthe ...
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Andrew, Angeline ...
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Shen, Hongbing
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Hong, Yun-Chul
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Yuan, Jian-Min
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Bertazzi, Pier A ...
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Pesatori, Angela ...
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Ye, Yuanqing
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Diao, Nancy
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Su, Li
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Zhang, Ruyang
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Brhane, Yonathan
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Leighl, Natasha
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Johansen, Jakob ...
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Mellemgaard, And ...
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Saliba, Walid
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Haiman, Christop ...
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Wilkens, Lynne R ...
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Fernandez-Somoan ...
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Fernandez-Tardon ...
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van der Heijden, ...
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Kim, Jin Hee
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Dai, Juncheng
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Hu, Zhibin
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Davies, Michael ...
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Marcus, Michael ...
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Brunnström, Hans
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Manjer, Jonas
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Melander, Olle
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Muller, David C.
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Overvad, Kim
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Trichopoulou, An ...
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Tumino, Rosario
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Doherty, Jennife ...
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Barnett, Matt P.
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Chen, Chu
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Goodman, Gary E.
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Cox, Angela
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Taylor, Fiona
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Woll, Penella
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Brüske, Irene
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Wichmann, H-Eric ...
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Manz, Judith
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Muley, Thomas R.
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Risch, Angela
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Rosenberger, Alb ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Shepherd, France ...
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Tsao, Ming-Sound
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Arnold, Susanne ...
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Haura, Eric B.
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Bolca, Ciprian
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Holcatova, Ivana
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Janout, Vladimir
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Kontic, Milica
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Lissowska, Jolan ...
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Mukeria, Anush
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Ognjanovic, Simo ...
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Orlowski, Tadeus ...
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Scelo, Ghislaine
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Swiatkowska, Bea ...
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Zaridze, David
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Bakke, Per
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Skaug, Vidar
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Zienolddiny, Sha ...
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Duell, Eric J.
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Butler, Lesley M ...
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Koh, Woon-Puay
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Gao, Yu-Tang
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Houlston, Richar ...
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McLaughlin, John
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Stevens, Victori ...
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Joubert, Philipp ...
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Lamontagne, Maxi ...
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Nickle, David C.
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Obeidat, Ma'en
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Timens, Wim
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Zhu, Bin
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Song, Lei
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Kachuri, Linda
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Artigas, Maria S ...
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Tobin, Martin D.
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Wain, Louise V.
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Rafnar, Thorunn
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Thorgeirsson, Th ...
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Reginsson, Gunna ...
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Stefansson, Kari
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Hancock, Dana B.
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Bierut, Laura J.
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Spitz, Margaret ...
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Gaddis, Nathan C ...
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Lutz, Sharon M.
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Gu, Fangyi
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Johnson, Eric O.
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Kamal, Ahsan
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Pikielny, Claudi ...
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Zhu, Dakai
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Lindström, Sara
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Jiang, Xia
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Tyndale, Rachel ...
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Chenevix-Trench, ...
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Beesley, Jonatha ...
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Bossé, Yohan
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Chanock, Stephen
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Brennan, Paul
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Landi, Maria Ter ...
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Amos, Christophe ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University
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Lund University
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Karolinska Institutet