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Pre-diagnostic C-re...
Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
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- Nimptsch, Katharina (författare)
- Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Aleksandrova, Krasimira (författare)
- Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
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- Fedirko, Veronika (författare)
- Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, TX, Houston, United States; Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Siersema, Peter D. (författare)
- Department of Gastroenterology and Hepatology, Radboud university medical center, Nijmegen, Netherlands
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- Wu, Kana (författare)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Katzke, Verena (författare)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Kaaks, Rudolf (författare)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Panico, Salvatore (författare)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Palli, Domenico (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy
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- May, Anne M (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Sieri, Sabina (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy
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- Bueno-de-Mesquita, Bas (författare)
- Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, Netherlands
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- Standahl, Karina (författare)
- Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
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- Sánchez, Maria-Jose (författare)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Perez-Cornago, Aurora (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Olsen, Anja (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Århus, Århus, Denmark
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Bonet, Catalina Bonet (författare)
- Unit of Nutrition and Cancer, Catalan Institute of Oncology – ICO, Barcelona, Spain; Nutrition and Cancer Group, Bellvitge Biomedical Research Institute – IDIBELL, Barcelona, Spain; L’Hospitalet de Llobregat, Barcelona, Spain
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- Dahm, Christina C. (författare)
- Department of Public Health, University of Århus, Århus, Denmark
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- Chirlaque, María-Dolores (författare)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain
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- Fiano, Valentina (författare)
- Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department Provincial Health Authority (ASP 7), Ragusa, Italy
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- Gurrea, Aurelio Barricarte (författare)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
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- Boutron-Ruault, Marie-Christine (författare)
- Paris-Saclay University, UVSQ, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, Inserm, Villejuif, France
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- Menegaux, Florence (författare)
- Paris-Saclay University, UVSQ, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, Inserm, Villejuif, France
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- Severi, Gianluca (författare)
- Paris-Saclay University, UVSQ, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, Inserm, Villejuif, France; Department of Statistics, Computer Science and Applications “G. Parenti” (DISIA), University of Florence, Florence, Italy
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Lee, Young-Ae (författare)
- Genetics of Allergic Disease Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Pediatric Allergy Experimental and Clinical Research Center, Charité Campus Buch, Berlin, Germany
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- Pischon, Tobias (författare)
- Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Charité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin, Germany; Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Biobank Technology Platform, Berlin, Germany; Core Facility Biobank, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
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Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Department of Nutrition, Harvard TH. Chan School of Public Health, MA, Boston, United States Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany (creator_code:org_t)
- 2022-06-24
- 2022
- Engelska.
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Ingår i: BMC Cancer. - : BioMed Central (BMC). - 1471-2407. ; 22:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.Methods: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression.Results: During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively).Conclusions: The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Nimptsch, Kathar ...
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Aleksandrova, Kr ...
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Fedirko, Veronik ...
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Jenab, Mazda
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Gunter, Marc J.
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Siersema, Peter ...
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visa fler...
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Wu, Kana
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Katzke, Verena
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Kaaks, Rudolf
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Panico, Salvator ...
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Palli, Domenico
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May, Anne M
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Sieri, Sabina
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Bueno-de-Mesquit ...
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Standahl, Karina
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Sánchez, Maria-J ...
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Perez-Cornago, A ...
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Olsen, Anja
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Tjønneland, Anne
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Bonet, Catalina ...
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Dahm, Christina ...
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Chirlaque, María ...
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Fiano, Valentina
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Tumino, Rosario
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Gurrea, Aurelio ...
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Boutron-Ruault, ...
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Menegaux, Floren ...
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Severi, Gianluca
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van Guelpen, Bet ...
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Lee, Young-Ae
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Pischon, Tobias
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