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  • Aguilo, FrancescaDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA (author)

THAP1 : role in mouse embryonic stem cell survival and differentiation

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Cell Press,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-137943
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137943URI
  • https://doi.org/10.1016/j.stemcr.2017.04.032DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • THAP1 (THAP [Thanatos-associated protein] domain-containing, apoptosis-associated protein 1) is a ubiquitously expressed member of a family of transcription factors with highly conserved DNA-binding and protein-interacting regions. Mutations in THAP1 cause dystonia, DYT6, a neurologic movement disorder. THAP1 downstream targets and the mechanism via which it causes dystonia are largely unknown. Here, we show that wild-type THAP1 regulates embryonic stem cell (ESC) potential, survival, and proliferation. Our findings identify THAP1 as an essential factor underlying mouse ESC survival and to some extent, differentiation, particularly neuroectodermal. Loss of THAP1 or replacement with a disease-causing mutation results in an enhanced rate of cell death, prolongs Nanog, Prdm14, and/or Rex1 expression upon differentiation, and results in failure to upregulate ectodermal genes. ChIP-Seq reveals that these activities are likely due in part to indirect regulation of gene expression.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zakirova, Zuchra (author)
  • Nolan, Katie (author)
  • Wagner, Ryan (author)
  • Sharma, Rajal (author)
  • Hogan, Megan (author)
  • Wei, Chengguo (author)
  • Sun, Yifei (author)
  • Walsh, Martin J. (author)
  • Kelley, Kevin (author)
  • Zhang, Weijia (author)
  • Ozelius, Laurie J. (author)
  • Gonzalez-Alegre, Pedro (author)
  • Zwaka, Thomas P. (author)
  • Ehrlich, Michelle E. (author)
  • Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA (creator_code:org_t)

Related titles

  • In:Stem Cell Reports: Cell Press9:1, s. 92-1072213-6711

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