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Genetic variation i...
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Nimptsch, KatharinaMax Delbrück Center for Molecular Medicine (MDC),Harvard University
(author)
Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization analysis using data from three large cohort studies
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-05-26
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Springer Science and Business Media LLC,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-137987
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137987URI
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https://doi.org/10.1007/s10654-017-0262-yDOI
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https://lup.lub.lu.se/record/6febbb2a-f866-4b84-825e-c51f20565a25URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136165889URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold higher adiponectin was not significantly associated with risk of colorectal cancer using the ADIPOQ allele score as instrumental variable (pooled OR 0.73, 95% CI 0.40, 1.34). In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. Due to the limited genetic determination of adiponectin, larger Mendelian Randomization studies are necessary to clarify whether adiponectin is causally related to lower risk of colorectal cancer.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Song, MingyangHarvard University
(author)
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Aleksandrova, KrasimiraGerman Institute of Human Nutrition
(author)
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Katsoulis, MichailHellenic Health Foundation, Athens,Farr Institute of Health Informatics Research
(author)
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Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization
(author)
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Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization,Imperial College London
(author)
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Gunter, Marc J.International Agency for Research on Cancer, World Health Organization,Max Delbrück Center for Molecular Medicine (MDC)
(author)
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Tsilidis, Konstantinos K.University of Ioannina,Imperial College London
(author)
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Weiderpass, ElisabeteKarolinska Institutet,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Folkhälsan Research Center
(author)
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Bueno-De-Mesquita, H. BasUniversity of Malaya,National Institute for Public Health and the Environment (RIVM),Imperial College London
(author)
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Chong, Dawn Q.National Cancer Centre Singapore
(author)
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Jensen, Majken K.Brigham and Women's Hospital / Harvard Medical School,Harvard University
(author)
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Wu, ChunsenOdense University Hospital,University of Southern Denmark,Aarhus University
(author)
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Overvad, KimAarhus University
(author)
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Kuehn, TilmanGerman Cancer Research Centre
(author)
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Barrdahl, MyrtoGerman Cancer Research Centre
(author)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji
(author)
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Peeters, Petra H.Imperial College London,University Medical Center Utrecht
(author)
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Sieri, SabinaIstituto Nazionale dei Tumori,Dana-Farber Cancer Institute,Brigham and Women's Hospital / Harvard Medical School
(author)
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Panico, SalvatoreUniversity of Naples Federico II
(author)
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Cross, Amanda J.
(author)
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Riboli, ElioImperial College London
(author)
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Van Guelpen, BethanyUmeå University,Umeå universitet,Onkologi(Swepub:umu)beyvan99
(author)
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Myte, RobinUmeå University,Umeå universitet,Onkologi(Swepub:umu)romy0001
(author)
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Maria Huerta, JoseCIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
(author)
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Rodriguez-Barranco, MiguelUniversity of Granada,CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Ramon Quiros, JosePublic Health Directorate
(author)
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Dorronsoro, MirenCIBER Epidemiology and Public Health (CIBERESP)
(author)
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Tjonneland, AnneDanish Cancer Society
(author)
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Olsen, AnjaDanish Cancer Society
(author)
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Travis, RuthUniversity of Oxford
(author)
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Boutron-Ruault, Marie-ChristineUniversity of Paris-Saclay
(author)
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Carbonnel, FranckUniversity of Paris-Saclay
(author)
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Severi, GianlucaUniversity of Melbourne,University of Paris-Saclay,Human Genetics Foundation (HuGeF)
(author)
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Bonet, CatalinaCatalan Institute of Oncology
(author)
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Palli, DomenicoCancer Research and Prevention Institute (ISPO)
(author)
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Janke, Juergen
(author)
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Lee, Young-AeMax Delbrück Center for Molecular Medicine (MDC)
(author)
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Boeing, HeinerGerman Institute of Human Nutrition
(author)
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Giovannucci, Edward L.Brigham and Women's Hospital / Harvard Medical School,Harvard University
(author)
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Ogino, ShujiBrigham and Women's Hospital / Harvard Medical School,Harvard University,Dana-Farber Cancer Institute
(author)
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Fuchs, Charles S.
(author)
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Rimm, EricBrigham and Women's Hospital / Harvard Medical School,Harvard University
(author)
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Wu, KanaHarvard University
(author)
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Chan, Andrew T.Brigham and Women's Hospital / Harvard Medical School,Broad Institute
(author)
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Pischon, TobiasCharité - University Medicine Berlin,Max Delbrück Center for Molecular Medicine (MDC)
(author)
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Max Delbrück Center for Molecular Medicine (MDC)Harvard University
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In:European Journal of Epidemiology: Springer Science and Business Media LLC32:5, s. 419-4300393-29901573-7284
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Nimptsch, Kathar ...
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Song, Mingyang
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Aleksandrova, Kr ...
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Katsoulis, Micha ...
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Freisling, Heinz
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Jenab, Mazda
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Gunter, Marc J.
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Tsilidis, Konsta ...
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Weiderpass, Elis ...
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Bueno-De-Mesquit ...
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Chong, Dawn Q.
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Jensen, Majken K ...
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Wu, Chunsen
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Overvad, Kim
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Kuehn, Tilman
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Barrdahl, Myrto
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Melander, Olle
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Jirström, Karin
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Peeters, Petra H ...
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Sieri, Sabina
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Panico, Salvator ...
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Cross, Amanda J.
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Riboli, Elio
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Van Guelpen, Bet ...
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Myte, Robin
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Maria Huerta, Jo ...
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Rodriguez-Barran ...
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Ramon Quiros, Jo ...
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Dorronsoro, Mire ...
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Tjonneland, Anne
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Olsen, Anja
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Travis, Ruth
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Boutron-Ruault, ...
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Carbonnel, Franc ...
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Severi, Gianluca
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Bonet, Catalina
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Palli, Domenico
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Janke, Juergen
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Lee, Young-Ae
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Boeing, Heiner
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Giovannucci, Edw ...
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Ogino, Shuji
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Fuchs, Charles S ...
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Rimm, Eric
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Wu, Kana
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Chan, Andrew T.
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Pischon, Tobias
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Umeå University
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Lund University
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Karolinska Institutet