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  • Nimptsch, KatharinaMax Delbrück Center for Molecular Medicine (MDC),Harvard University (författare)

Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization analysis using data from three large cohort studies

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-05-26
  • Springer Science and Business Media LLC,2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-137987
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137987URI
  • https://doi.org/10.1007/s10654-017-0262-yDOI
  • https://lup.lub.lu.se/record/6febbb2a-f866-4b84-825e-c51f20565a25URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136165889URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold higher adiponectin was not significantly associated with risk of colorectal cancer using the ADIPOQ allele score as instrumental variable (pooled OR 0.73, 95% CI 0.40, 1.34). In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. Due to the limited genetic determination of adiponectin, larger Mendelian Randomization studies are necessary to clarify whether adiponectin is causally related to lower risk of colorectal cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Song, MingyangHarvard University (författare)
  • Aleksandrova, KrasimiraGerman Institute of Human Nutrition (författare)
  • Katsoulis, MichailHellenic Health Foundation, Athens,Farr Institute of Health Informatics Research (författare)
  • Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization (författare)
  • Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization,Imperial College London (författare)
  • Gunter, Marc J.International Agency for Research on Cancer, World Health Organization,Max Delbrück Center for Molecular Medicine (MDC) (författare)
  • Tsilidis, Konstantinos K.Imperial College London,University of Ioannina (författare)
  • Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø,Folkhälsan Research Center (författare)
  • Bueno-De-Mesquita, H. BasImperial College London,University of Malaya,National Institute for Public Health and the Environment (RIVM) (författare)
  • Chong, Dawn Q.National Cancer Centre Singapore (författare)
  • Jensen, Majken K.Harvard University,Brigham and Women's Hospital / Harvard Medical School (författare)
  • Wu, ChunsenUniversity of Southern Denmark,Aarhus University,Odense University Hospital (författare)
  • Overvad, KimAarhus University (författare)
  • Kuehn, TilmanGerman Cancer Research Centre (författare)
  • Barrdahl, MyrtoGerman Cancer Research Centre (författare)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (författare)
  • Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji (författare)
  • Peeters, Petra H.Imperial College London,University Medical Center Utrecht (författare)
  • Sieri, SabinaIstituto Nazionale dei Tumori,Brigham and Women's Hospital / Harvard Medical School,Dana-Farber Cancer Institute (författare)
  • Panico, SalvatoreUniversity of Naples Federico II (författare)
  • Cross, Amanda J. (författare)
  • Riboli, ElioImperial College London (författare)
  • Van Guelpen, BethanyUmeå University,Umeå universitet,Onkologi(Swepub:umu)beyvan99 (författare)
  • Myte, RobinUmeå University,Umeå universitet,Onkologi(Swepub:umu)romy0001 (författare)
  • Maria Huerta, JoseMurcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Rodriguez-Barranco, MiguelCIBER Epidemiology and Public Health (CIBERESP),University of Granada (författare)
  • Ramon Quiros, JosePublic Health Directorate (författare)
  • Dorronsoro, MirenCIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Tjonneland, AnneDanish Cancer Society (författare)
  • Olsen, AnjaDanish Cancer Society (författare)
  • Travis, RuthUniversity of Oxford (författare)
  • Boutron-Ruault, Marie-ChristineUniversity of Paris-Saclay (författare)
  • Carbonnel, FranckUniversity of Paris-Saclay (författare)
  • Severi, GianlucaUniversity of Melbourne,University of Paris-Saclay,Human Genetics Foundation (HuGeF) (författare)
  • Bonet, CatalinaCatalan Institute of Oncology (författare)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (författare)
  • Janke, Juergen (författare)
  • Lee, Young-AeMax Delbrück Center for Molecular Medicine (MDC) (författare)
  • Boeing, HeinerGerman Institute of Human Nutrition (författare)
  • Giovannucci, Edward L.Harvard University,Brigham and Women's Hospital / Harvard Medical School (författare)
  • Ogino, ShujiDana-Farber Cancer Institute,Harvard University,Brigham and Women's Hospital / Harvard Medical School (författare)
  • Fuchs, Charles S. (författare)
  • Rimm, EricHarvard University,Brigham and Women's Hospital / Harvard Medical School (författare)
  • Wu, KanaHarvard University (författare)
  • Chan, Andrew T.Broad Institute,Brigham and Women's Hospital / Harvard Medical School (författare)
  • Pischon, TobiasMax Delbrück Center for Molecular Medicine (MDC),Charité - University Medicine Berlin (författare)
  • Max Delbrück Center for Molecular Medicine (MDC)Harvard University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Epidemiology: Springer Science and Business Media LLC32:5, s. 419-4300393-29901573-7284

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