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Early pregnancy sex...
Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer : a nested case-control study in the Northern Sweden Maternity Cohort
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Fortner, Renee T. (author)
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- Tolockiene, Egle (author)
- Umeå universitet,Patologi
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Schock, Helena (author)
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- Oda, Husam (author)
- Umeå universitet,Patologi
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- Lakso, Hans-Åke (author)
- Umeå universitet,Klinisk kemi
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning,Arcum
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Kaaks, Rudolf (author)
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Toniolo, Paolo (author)
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Zeleniuch-Jacquotte, Anne (author)
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- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2017-07-18
- 2017
- English.
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In: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 19
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://breast-cance...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones.Methods: We conducted a nested case–control study in the Northern Sweden Maternity Cohort (1975–2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection). Estrogen receptor (ER) and progesterone receptor (PR) status was available for all cases; androgen receptor (AR) data were available for 41% of cases (n = 92). Sex steroids were quantified by high-performance liquid chromatography tandem mass spectrometry. Odds ratios (ORs) and 95% confidence intervals were estimated using conditional logistic regression.Results: Higher concentrations of circulating progesterone in early pregnancy were inversely associated with ER+/PR+ breast cancer risk (ORlog2: 0.64 (0.41–1.00)). Higher testosterone was positively associated with ER+/PR+ disease risk (ORlog2: 1.57 (1.13–2.18)). Early pregnancy estrogens were not associated with risk, except for relatively high estradiol in the context of low progesterone (split at median, relative to low concentrations of both; OR: 1.87 (1.11–3.16)). None of the investigated hormones were associated with ER–/PR– disease, or with AR+ or AR+/ER+/PR+ disease.Conclusions: Consistent with experimental models, high progesterone in early pregnancy was associated with lower risk of ER+/PR+ breast cancer in the mother. High circulating testosterone in early pregnancy, which likely reflects nonpregnant premenopausal exposure, was associated with higher risk of ER+/PR+ disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Endogenous hormones
- Early pregnancy
- Breast cancer
- Sex steroids
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fortner, Renee T ...
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Tolockiene, Egle
-
Schock, Helena
-
Oda, Husam
-
Lakso, Hans-Åke
-
Hallmans, Göran
-
show more...
-
Kaaks, Rudolf
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Toniolo, Paolo
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Zeleniuch-Jacquo ...
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Grankvist, Kjell
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Lundin, Eva
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Breast Cancer Re ...
- By the university
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Umeå University