Search: (WFRF:(Helzlsouer Kathy J)) pers:(Weiderpass Elisabete) >
Androgens Are Diffe...
Androgens Are Differentially Associated with Ovarian Cancer Subtypes in the Ovarian Cancer Cohort Consortium
- Article/chapterEnglish2017
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-138036
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138036URI
-
https://doi.org/10.1158/0008-5472.CAN-16-3322DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:136252735URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Invasive epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. Research on prediagnosis androgen concentrations and EOC risk has yielded inconclusive results, and analyses incorporating EOC subtypes are sparse. We conducted a pooled analysis of 7 nested case–control studies in the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis circulating androgens [testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS)], sex hormone binding globulin (SHBG), and EOC risk by tumor characteristics (i.e., histology, grade, and stage). The final study population included 1,331 EOC cases and 3,017 matched controls. Multivariable conditional logistic regression was used to assess risk associations in pooled individual data. Testosterone was positively associated with EOC risk (all subtypes combined, ORlog2 = 1.12; 95% confidence interval 1.02–1.24); other endogenous androgens and SHBG were not associated with overall risk. Higher concentrations of testosterone and androstenedione associated with an increased risk in endometrioid and mucinous tumors [e.g., testosterone, endometrioid tumors, ORlog2 = 1.40 (1.03–1.91)], but not serous or clear cell. An inverse association was observed between androstenedione and high grade serous tumors [ORlog2 = 0.76 (0.60–0.96)]. Our analyses provide further evidence for a role of hormone-related pathways in EOC risk, with differences in associations between androgens and histologic subtypes of EOC.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Poole, Elizabeth M.
(author)
-
Schock, Helena
(author)
-
Lehtinen, MattiKarolinska Institutet
(author)
-
Arslan, Alan A.
(author)
-
Zeleniuch-Jacquotte, Anne
(author)
-
Visvanathan, Kala
(author)
-
Helzlsouer, Kathy
(author)
-
Buring, Julie E.
(author)
-
Lee, I-Min
(author)
-
Tjonneland, Anne
(author)
-
Dossus, Laure
(author)
-
Trichopoulou, Antonia
(author)
-
Masala, Giovanna
(author)
-
Onland-Moret, N. Charlotte
(author)
-
Weiderpass, ElisabeteKarolinska Institutet
(author)
-
Duell, Eric J.
(author)
-
Idahl, AnnikaUmeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002
(author)
-
Travis, Ruth C.
(author)
-
Rinaldi, Sabina
(author)
-
Merritt, Melissa A.
(author)
-
Trabert, Britton
(author)
-
Wentzensen, Nicolas
(author)
-
Tworoger, Shelley S.
(author)
-
Kaaks, Rudolf
(author)
-
Fortner, Renee T.
(author)
-
Karolinska InstitutetObstetrik och gynekologi
(creator_code:org_t)
Related titles
-
In:Cancer Research77:14, s. 3951-39600008-54721538-7445
Internet link
Find in a library
To the university's database
- By the author/editor
-
Ose, Jennifer
-
Poole, Elizabeth ...
-
Schock, Helena
-
Lehtinen, Matti
-
Arslan, Alan A.
-
Zeleniuch-Jacquo ...
-
show more...
-
Visvanathan, Kal ...
-
Helzlsouer, Kath ...
-
Buring, Julie E.
-
Lee, I-Min
-
Tjonneland, Anne
-
Dossus, Laure
-
Trichopoulou, An ...
-
Masala, Giovanna
-
Onland-Moret, N. ...
-
Weiderpass, Elis ...
-
Duell, Eric J.
-
Idahl, Annika
-
Travis, Ruth C.
-
Rinaldi, Sabina
-
Merritt, Melissa ...
-
Trabert, Britton
-
Wentzensen, Nico ...
-
Tworoger, Shelle ...
-
Kaaks, Rudolf
-
Fortner, Renee T ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
Cancer Research
- By the university
-
Umeå University
-
Karolinska Institutet