Increased vitamin D intake differentiated according to skin color is needed to meet requirements in young Swedish children during winter: a double-blind randomized clinical trial

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Öhlund, IngerUmeå University,Umeå universitet,Pediatrik (författare)

Increased vitamin D intake differentiated according to skin color is needed to meet requirements in young Swedish children during winter : a double-blind randomized clinical trial

Artikel/kapitelEngelska2017

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American Society for Nutrition,2017
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:umu-138554
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138554URI
https://doi.org/10.3945/ajcn.116.147108DOI
https://lup.lub.lu.se/record/f6b7516c-df92-4f50-b24e-0c4d588cfde1URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

Anmärkningar

Background: Dark skin and low exposure to sunlight increase the risk of vitamin D insufficiency in children. Objective: The aim of the study was to evaluate the amount of vitamin D needed to ascertain that most children >4 y of age attain sufficient serum25-hydroxyvitamin D [S-25(OH) D; i.e., >= 50 nmol/L] during winter regardless of latitude and skin color. Design: In a longitudinal, double-blind, randomized, food-based intervention study, 5- to 7-y-old children from northern (638 degrees N) and southern (558 degrees N) Sweden with fair (n = 108) and dark (n = 98) skin were included. Children, stratified by skin color by using Fitzpa-trick's definition, were randomly assigned to receive milk-based vitamin D-3 supplements that provided 2 (placebo), 10, or 25 mu g/d during 3 winter months. Results: Mean daily vitamin D intake increased from 6 to 17 mu g and 26 mu g in the intervention groups supplemented with 10 and 25 mu g, respectively. In the intention-to-treat analysis, 90.2% (95% CI: 81.1%, 99.3%) of fair-skinned children randomly assigned to supplementation of 10 mu g/d attained sufficient concentrations, whereas 25 mu g/d was needed in dark-skinned children to reach sufficiency in 95.1% (95% CI: 88.5%, 100%). In children adherent to the study product, 97% (95% CI: 91.3%, 100%) and 87.9% (95% CI: 76.8%, 99%) of fair-and dark-skinned children, respectively, achieved sufficient concentrations if supplemented with 10 mu g/d. By using 95% prediction intervals for 30 and 50 nmol S-25(OH) D/L, intakes of 6 and 20 mu g/d are required in fair-skinned children, whereas 14 and 28 mu g/d are required in children with dark skin. Conclusion: Children with fair and dark skin require vitamin D intakes of 20 and 28 mu g/d, respectively, to maintain S-25(OH) D >= 50 nmol/L, whereas intakes of 6 and 14 mu g/d, respectively, are required to maintain concentrations >= 30 nmol/L during winter.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
serum 25-hydroxyvitamin D
intervention
season
latitude
vitamin D
child
Child
Intervention
Latitude
Season
Serum 25-hydroxyVitamin D
Vitamin D

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lind, TorbjörnUmeå University,Umeå universitet,Pediatrik(Swepub:umu)toli0008 (författare)
Hernell, OlleUmeå University,Umeå universitet,Pediatrik(Swepub:umu)olhe0002 (författare)
Silfverdal, Sven-ArneUmeå University,Umeå universitet,Pediatrik(Swepub:umu)svar0002 (författare)
Äkeson, Pia KarlslandLund University,Lunds universitet,Preventiv pediatrik,Forskargrupper vid Lunds universitet,Preventive Paediatrics,Lund University Research Groups(Swepub:lu)pedi-pka (författare)
Umeå universitetPediatrik (creator_code:org_t)

Sammanhörande titlar

Ingår i:American Journal of Clinical Nutrition: American Society for Nutrition106:1, s. 105-1120002-91651938-3207

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Av författaren/redakt...: Öhlund, Inger; Lind, Torbjörn; Hernell, Olle; Silfverdal, Sven ...; Äkeson, Pia Karl ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Näringslära

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Av lärosätet: Umeå universitet; Lunds universitet

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