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  • Li, Sherly X.University of Cambridge (author)

Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes : systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • American society for nutrition,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-138555
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138555URI
  • https://doi.org/10.3945/ajcn.116.150094DOI
  • https://lup.lub.lu.se/record/755e4996-b952-444f-93a5-777faa86bc80URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Background: Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date. Objective: We aimed to identify existing evidence for genemacronutrient interactions and T2D and to examine the reported interactions in a large-scale study. Design: We systematically reviewed studies reporting genemacronutrient interactions and T2D. We searched the MEDLINE, Human Genome Epidemiology Network, and WHO International Clinical Trials Registry Platform electronic databases to identify studies published up to October 2015. Eligibility criteria included assessment of macronutrient quantity (e.g., total carbohydrate) or indicators of quality (e. g., dietary fiber) by use of self-report or objective biomarkers of intake. Interactions identified in the review were subsequently examined in the EPIC (European Prospective Investigation into Cancer)-InterAct case-cohort study (n = 21,148, with 9403 T2D cases; 8 European countries). Prentice-weighted Cox regression was used to estimate countryspecific HRs, 95% CIs, and P-interaction values, which were then pooled by random-effects meta-analysis. A primary model was fitted by using the same covariates as reported in the published studies, and a second model adjusted for additional covariates and estimated the effects of isocaloric macronutrient substitution. Results: Thirteen observational studies met the eligibility criteria (n < 1700 cases). Eight unique interactions were reported to be significant between macronutrients [carbohydrate, fat, saturated fat, dietary fiber, and glycemic load derived from self-report of dietary intake and circulating n-3 (v-3) polyunsaturated fatty acids] and genetic variants in or near transcription factor 7-like 2 (TCF7L2), gastric inhibitory polypeptide receptor (GIPR), caveolin 2 (CAV2), and peptidase D (PEPD) (P-interaction, 0.05). We found no evidence of interaction when we tried to replicate previously reported interactions. In addition, no interactions were detected in models with additional covariates. Conclusions: Eight gene-macronutrient interactions were identified for the risk of T2D from the literature. These interactions were not replicated in the EPIC-InterAct study, which mirrored the analyses undertaken in the original reports. Our findings highlight the importance of independent replication of reported interactions.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Imamura, FumiakiUniversity of Cambridge (author)
  • Ye, ZhengUniversity of Cambridge (author)
  • Schulze, Matthias B.German Center for Diabetes Research,German Institute of Human Nutrition (author)
  • Zheng, JushengUniversity of Cambridge (author)
  • Ardanaz, EvaHealth Research Institute of Navarra (IDISNA) (author)
  • Arriola, LarraitzPublic Health Division of Gipuzkoa (author)
  • Boeing, HeinerGerman Institute of Human Nutrition (author)
  • Dow, CourtneyUniversity of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP) (author)
  • Fagherazzi, GuyUniversity of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP) (author)
  • Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Medicin,Lund Univ, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf (author)
  • Agudo, AntonioCatalan Institute of Oncology,German Cancer Research Centre,University of Cambridge (author)
  • Grioni, Sara (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Katzke, Verena A. (author)
  • Key, Timothy J.University of Oxford (author)
  • Khaw, Kay TeeUniversity of Cambridge (author)
  • Mancini, Francesca R.Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay (author)
  • Navarro, CarmenUniversity of Murcia,Murcia Regional Health Council (author)
  • Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
  • Onland-Moret, N. CharlotteUniversity Medical Center Utrecht (author)
  • Overvad, KimAalborg University,Aarhus University (author)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Quiros, J. Ramon (author)
  • Rolandsson, OlovUmeå University,Umeå universitet,Allmänmedicin(Swepub:umu)olro0005 (author)
  • Sacerdote, CarlottaCentre for Cancer Epidemiology and Prevention (CPO Piemonte),Citta' della Salute e della Scienza Hospital-University of Turin,Human Genetics Foundation (HuGeF) (author)
  • Sanchez, Maria-JoseAndalusian School Of Public Health (EASP) (author)
  • Slimani, NadiaInternational Agency for Research on Cancer, World Health Organization (author)
  • Sluijs, IvonneUniversity Medical Center Utrecht (author)
  • Spijkerman, Annemieke M. W.National Institute for Public Health and the Environment (RIVM) (author)
  • Tjonneland, AnneDanish Cancer Society (author)
  • Tumino, Rosario (author)
  • Sharp, Stephen J.University of Cambridge (author)
  • Riboli, ElioImperial College London (author)
  • Langenberg, ClaudiaUniversity of Cambridge (author)
  • Scott, Robert A. (author)
  • Forouhi, Nita G.University of Cambridge (author)
  • Wareham, Nicholas J.University of Cambridge (author)
  • University of CambridgeGerman Center for Diabetes Research (creator_code:org_t)

Related titles

  • In:American Journal of Clinical Nutrition: American society for nutrition106:1, s. 263-2750002-91651938-3207

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