Increased Risk of Drug-Induced Hyponatremia during High Temperatures

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Jönsson, Anna K.National Board Forens Med, Department Forens Genet and Forens Toxicol, S-58758 Linkoping, Sweden (författare)

Increased Risk of Drug-Induced Hyponatremia during High Temperatures

Artikel/kapitelEngelska2017

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2017-07-22
MDPI AG,2017
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-139162
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-139162URI
https://doi.org/10.3390/ijerph14070827DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-140807URI

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Språk:engelska
Sammanfattning på:engelska

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Funding Agencies|County Council of Ostergotland [LIO-448321]; Umea Centre for Global Health Research at Umea University; FORTE; Swedish Council for Working Life and Social Research [2006 1512]
Purpose: To investigate the relationship between outdoor temperature in Sweden and the reporting of drug-induced hyponatremia to the Medical Products Agency (MPA). Methods: All individual adverse drug reactions (ADR) reported to MPA from 1 January 2010 to 31 October 2013 of suspected drug-induced hyponatremia and random controls were identified. Reports where the ADR had been assessed as having at least a possible relation to the suspected drug were included. Information on administered drugs, onset date, causality assessment, sodium levels, and the geographical origin of the reports was extracted. A case-crossover design was used to ascertain the association between heat exposure and drug-induced hyponatremia at the individual level, while linear regression was used to study its relationship to sodium concentration in blood. Temperature exposure data were obtained from the nearest observation station to the reported cases. Results: During the study period, 280 reports of hyponatremia were identified. More cases of drug-induced hyponatremia were reported in the warmer season, with a peak in June, while other ADRs showed an opposite annual pattern. The distributed lag non-linear model indicated an increasing odds ratio (OR) with increasing temperature in the warm season with a highest odds ratio, with delays of 1-5 days after heat exposure. A cumulative OR for a lag time of 1 to 3 days was estimated at 2.21 at an average daily temperature of 20 degrees C. The change in sodium per 1 degrees C increase in temperature was estimated to be -0.37 mmol/L (95% CI: -0.02, -0.72). Conclusions: Warm weather appears to increase the risk of drug-induced hyponatremia.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
average daily temperature
hyponatremia
adverse drug reaction

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lövborg, HenrikLinköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi(Swepub:liu)henlo57 (författare)
Lohr, WolfgangUmeå universitet,Epidemiologi och global hälsa,Umeå University, Sweden(Swepub:umu)wolo0003 (författare)
Ekman, Bertil,1958-Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)berek83 (författare)
Rocklöv, JoacimUmeå universitet,Epidemiologi och global hälsa,Institute of Public Health, Heidelberg University, Heidelberg, Germany,Umeå University, Sweden; Heidelberg University, Germany(Swepub:umu)joro0003 (författare)
National Board Forens Med, Department Forens Genet and Forens Toxicol, S-58758 Linkoping, SwedenAvdelningen för läkemedelsforskning (creator_code:org_t)

Sammanhörande titlar

Ingår i:International Journal of Environmental Research and Public Health: MDPI AG14:71661-78271660-4601

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Av författaren/redakt...: Jönsson, Anna K.; Lövborg, Henrik; Lohr, Wolfgang; Ekman, Bertil, 1 ...; Rocklöv, Joacim

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

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Av lärosätet: Umeå universitet; Linköpings universitet

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