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Using Functional Ma...
Using Functional Magnetic Resonance Imaging to Detect Chronic Fatigue in Patients With Previous Traumatic Brain Injury : changes linked to altered Striato-Thalamic-Cortical Functioning
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- Berginström, Nils (author)
- Umeå universitet,Geriatrik
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- Nordström, Peter (author)
- Umeå universitet,Geriatrik
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- Ekman, Urban (author)
- Karolinska Institutet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
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- Eriksson, Johan (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi
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- Andersson, Micael (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi
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- Nordström, Anna (author)
- Umeå universitet,Yrkes- och miljömedicin,Geriatrik
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(creator_code:org_t)
- Wolters Kluwer, 2018
- 2018
- English.
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In: The journal of head trauma rehabilitation. - : Wolters Kluwer. - 0885-9701 .- 1550-509X. ; 33:4, s. 266-274
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Abstract
Subject headings
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- Objective: To investigate whether functional magnetic resonance imaging (fMRI) can be used to detect fatigue after traumatic brain injury (TBI).Setting: Neurorehabilitation clinic.Participants: Patients with TBI (n = 57) and self-experienced fatigue more than 1 year postinjury, and age- and gender-matched healthy controls (n = 27).Main Measures: Self-assessment scales of fatigue, a neuropsychological test battery, and fMRI scanning during performance of a fatiguing 27-minute attention task.Results: During testing within the fMRI scanner, patients showed a higher increase in self-reported fatigue than controls from before to after completing the task (P < .001).The patients also showed lower activity in several regions, including bilateral caudate, thalamus, and anterior insula (all P < .05). Furthermore, the patients failed to display decreased activation over time in regions of interest: the bilateral caudate and anterior thalamus (all P < .01). Left caudate activity correctly identified 91% of patients and 81% of controls, resulting in a positive predictive value of 91%.Conclusion: The results suggest that chronic fatigue after TBI is associated with altered striato-thalamic-cortical functioning. It would be of interest to study whether fMRI can be used to support the diagnosis of chronic fatigue in future studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- fatigue
- functional magnetic resonance imaging
- neuropsychology
- traumatic brain injury
- rehabiliteringsmedicin
- Rehabilitation Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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