Leptin independently predicts development of sepsis and its outcome

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Jacobsson, SofieUmeå universitet,Anestesiologi och intensivvård (author)

Leptin independently predicts development of sepsis and its outcome

Article/chapterEnglish2017

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2017-09-11
London :BioMed Central (BMC),2017
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-140039
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140039URI
https://doi.org/10.1186/s12950-017-0167-2DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Background: Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be involved.Methods: Patients aged 18 years or more with documented first time sepsis events were included in a nested case-referent study if they had participated in previous health surveys. Two matched referents free of known sepsis were identified. Circulating levels of leptin and adiponectin were determined in stored plasma, and their impact on a future sepsis event and its outcome was evaluated.Results: We identified 152 patients (62% women) with a sepsis event and a previous participation in a health survey. Eighty-three % had also blood samples from the acute event. Hyperleptinemia at health survey associated with a future sepsis event (OR 1.77, 95% CI 1.04-3.00) and with hospital death. After adjustment for BMI leptin remained associated with sepsis in men, but not in women. High levels in the acute phase associated with increased risk for in hospital death in women (OR 4.18, 95% CI 1.17-15.00), while being protective in men (OR 0.05, 95% CI 0.01-0.48). Furthermore, leptin increased more from baseline to the acute phase in men than in women. Adiponectin did not predict sepsis and did not relate to outcome.Conclusions: Hyperleptinemia independently predicted the development of sepsis and an unfavourable outcome in men, and inertia in the acute response related to worse outcome.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Sepsis
Leptin
Adiponectin
Obesity
Case-referent study
Sex

Added entries (persons, corporate bodies, meetings, titles ...)

Larsson, PeterUmeå universitet,Anestesiologi och intensivvård(Swepub:umu)perlan96 (author)
Johansson, GöranUmeå universitet,Anestesiologi och intensivvård(Swepub:umu)gojo0001 (author)
Norberg, MargaretaUmeå universitet,Epidemiologi och global hälsa(Swepub:umu)mano0062 (author)
Wadell, GöranUmeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)gowa0001 (author)
Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
Winsö, OlaUmeå universitet,Anestesiologi och intensivvård(Swepub:umu)olwi0001 (author)
Söderberg, StefanUmeå universitet,Kardiologi(Swepub:umu)stso0001 (author)
Umeå universitetAnestesiologi och intensivvård (creator_code:org_t)

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In:Journal of InflammationLondon : BioMed Central (BMC)141476-9255

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By the author/editor: Jacobsson, Sofie; Larsson, Peter; Johansson, Göran; Norberg, Margare ...; Wadell, Göran; Hallmans, Göran; show more...; Winsö, Ola; Söderberg, Stefa ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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By the university: Umeå University

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