Sökning: L773:0910 8327 OR L773:1615 2573 >
Plasma l-arginine l...
Plasma l-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction
-
- Sandqvist, Anna (författare)
- Umeå University,Umeå universitet,Farmakologi,Umea Univ, Clin Pharmacol, Dept Pharmacol & Clin Neurosci, S-90187 Umea, Sweden.
-
- Schneede, Jörn (författare)
- Umeå University,Umeå universitet,Farmakologi,Umea Univ, Clin Pharmacol, Dept Pharmacol & Clin Neurosci, S-90187 Umea, Sweden.
-
- Kylhammar, David (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
-
visa fler...
-
- Henrohn, D (författare)
- Uppsala University,Uppsala universitet,Kardiologi
-
- Lundgren, Jakob (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
-
- Hedeland, Mikael (författare)
- Uppsala University,Uppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem, Uppsala, Sweden.,Swedish National Veterinary Institute
-
- Bondesson, Ulf (författare)
- Uppsala University,Uppsala universitet,Analytisk vetenskap,Natl Vet Inst SVA, Dept Chem, Uppsala, Sweden.,Swedish National Veterinary Institute
-
- Rådegran, Göran (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
-
- Wikström, Gerhard (författare)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.
-
visa färre...
-
(creator_code:org_t)
- 2017-10-03
- 2018
- Engelska.
-
Ingår i: Heart and Vessels. - : Springer. - 0910-8327 .- 1615-2573. ; 33:3, s. 255-263
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://link.springe...
-
https://uu.diva-port... (primary) (Raw object)
-
http://dx.doi.org/10... (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- Pulmonary arterial hypertension (PAH) is a life-threatening condition, characterized by an imbalance of vasoactive substances and remodeling of pulmonary vasculature. Nitric oxide, formed from l-arginine, is essential for homeostasis and smooth muscle cell relaxation in PAH. Our aim was to compare plasma concentrations of l-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) in PAH compared to left ventricular systolic dysfunction (LVSD) and healthy subjects. This was an observational, multicenter study comparing 21 patients with PAH to 14 patients with LVSD and 27 healthy subjects. Physical examinations were obtained and blood samples were collected. Plasma levels of ADMA, SDMA, l-arginine, l-ornithine, and l-citrulline were analyzed using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Plasma levels of ADMA and SDMA were higher, whereas l-arginine and l-arginine/ADMA ratio were lower in PAH patients compared to healthy subjects (p < 0.001). Patients with PAH also had lower levels of l-arginine than patients with LVSD (p < 0.05). l-Arginine correlated to 6 min walking distance (6MWD) (r s = 0.58, p = 0.006) and l-arginine/ADMA correlated to WHO functional class (r s = −0.46, p = 0.043) in PAH. In conclusion, l-arginine levels were significantly lower in treatment naïve PAH patients compared to patients with LVSD. Furthermore, l-arginine correlated with 6MWD in PAH. l-arginine may provide useful information in differentiating PAH from LVSD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Dimethylarginines
- L-Arginine
- Left heart failure
- Pulmonary arterial hypertension
- Systolic dysfunction
- kardiologi
- Cardiology
- Dimethylarginines
- l-Arginine
- Left heart failure
- Pulmonary arterial hypertension
- Systolic dysfunction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas