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Impact of Amyotroph...
Impact of Amyotrophic Lateral Sclerosis on Slow Tonic Myofiber Composition in Human Extraocular Muscles
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- Tjust, Anton E. (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Oftalmiatrik
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- Danielsson, Adam (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Andersen, Peter M. (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Brännstrom, Thomas (författare)
- Umeå universitet,Patologi
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- Pedrosa-Domellöf, Fatima (författare)
- Umeå universitet,Oftalmiatrik,Institutionen för integrativ medicinsk biologi (IMB),Klinisk neurovetenskap,Patologi
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(creator_code:org_t)
- ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017
- 2017
- Engelska.
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Ingår i: Investigative Ophthalmology and Visual Science. - : ASSOC RESEARCH VISION OPHTHALMOLOGY INC. - 0146-0404 .- 1552-5783. ; 58:9, s. 3708-3715
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE. To analyze the proportion and cross-sectional area of myofibers containing myosin heavy chain slow-twitch (MyHCI) and myosin heavy chain slow tonic (MyHCsto) in extraocular muscles of autopsied amyotrophic lateral sclerosis (ALS) patients with either spinal or bulbar site of disease onset. METHODS. Whole-muscle cross sections from the middle portion of the medial rectus were labeled with antibodies against MyHCI or MyHCsto and laminin. Myofibers labeled with the MyHC antibodies (MyHCI+sto) and the total number of myofibers were quantified in the orbital and global layer of 6 control individuals and 18 ALS patients. The cross-sectional area of myofibers labeled for either MyHC was quantified in 130 to 472 fibers/individual in the orbital and in 180 to 573 fibers/individual in the global layer of each specimen. RESULTS. The proportion of MyHCI+sto myofibers was significantly smaller in the orbital and global layer of ALS compared to control individuals. MyHCI+sto myofibers were significantly smaller in the global layer than in the orbital layer of ALS, whereas they were of similar size in control subjects. The decreased proportion of MyHCI+sto fibers correlated significantly with the age of death, but not disease duration, in patients who had the bulbar-onset variant of ALS but not in patients with spinal variant. CONCLUSIONS. ALS, regardless of site of onset, involves a loss of myofibers containing MyHCI+sto. Only in bulbar-onset cases did aging seem to play a role in the pathophysiological processes underlying the loss of MyHCI+sto fibers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- amyotrophic lateral sclerosis
- extraocular muscles
- MyH14
- slow tonic
- muscle fibers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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