Sökning: (WFRF:(Overvad Kim)) pers:(Spijkerman Annemieke M. W.) >
A combination of pl...
-
Imamura, FumiakiUniversity of Cambridge
(författare)
A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes : The EPIC-InterAct case-cohort study
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
-
2017-10-11
-
Public Library Science,2017
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-141998
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141998URI
-
https://doi.org/10.1371/journal.pmed.1002409DOI
-
https://lup.lub.lu.se/record/e121d8bd-6565-4e17-b9ed-14776c97f608URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Background Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated.Methods and findings We measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991-1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested casecohort study. The first principal component derived by principal component analysis of 27 individual fatty acids (mole percentage) was the main exposure (subsequently called the fatty acid pattern score [FA-pattern score]). The FA-pattern score was partly characterised by high concentrations of linoleic acid, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrations of.-linolenic acid, palmitic acid, and long-chain monounsaturated fatty acids, and it explained 16.1% of the overall variability of the 27 fatty acids. Based on country-specific Prentice-weighted Cox regression and random-effects meta-analysis, the FA-pattern score was associated with lower incident T2D. Comparing the top to the bottom fifth of the score, the hazard ratio of incident T2D was 0.23 (95% CI 0.19-0.29) adjusted for potential confounders and 0.37 (95% CI 0.27-0.50) further adjusted for metabolic risk factors. The association changed little after adjustment for individual fatty acids or fatty acid subclasses. In cross-sectional analyses relating the FA-pattern score to metabolic, genetic, and dietary factors, the FA-pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive protein, a genetic score representing insulin resistance, and dietary intakes of soft drinks and alcohol and was positively associated with high-density-lipoprotein cholesterol and intakes of polyunsaturated fat, dietary fibre, and coffee (p < 0.05 each). Limitations include potential measurement error in the fatty acids and other model covariates and possible residual confounding.Conclusions A combination of individual fatty acids, characterised by high concentrations of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower incidence of T2D. The specific fatty acid pattern may be influenced by metabolic, genetic, and dietary factors.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Sharp, Stephen J.University of Cambridge
(författare)
-
Koulman, AlbertMRC Human Nutrition Research,University of Cambridge
(författare)
-
Schulze, Matthias B.German Institute of Human Nutrition,University of Paris-Saclay
(författare)
-
Kröger, JanineGerman Institute of Human Nutrition
(författare)
-
Griffin, Julian L.University of Cambridge
(författare)
-
Huerta, José M.CIBER Epidemiology and Public Health (CIBERESP)
(författare)
-
Guevara, MarcelaCIBER Epidemiology and Public Health (CIBERESP)
(författare)
-
Sluijs, IvonneUniversity Medical Center Utrecht
(författare)
-
Agudo, AntonioCatalan Institute of Oncology
(författare)
-
Ardanaz, EvaCIBER Epidemiology and Public Health (CIBERESP)
(författare)
-
Balkau, Beverley
(författare)
-
Boeing, HeinerGerman Institute of Human Nutrition
(författare)
-
Chajes, VeroniqueInternational Agency for Research on Cancer, World Health Organization
(författare)
-
Dahm, Christina C.Aarhus University
(författare)
-
Dow, CourtneyUniversity of Paris-Saclay,Institut Gustave Roussy
(författare)
-
Fagherazzi, GuyInstitut Gustave Roussy,University of Paris-Saclay
(författare)
-
Feskens, Edith J. M.Wageningen University
(författare)
-
Franks, Paul W.Umeå University,Lund University,Lunds universitet,Umeå universitet,Allmänmedicin,Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-plf
(författare)
-
Gavrila, DianaCIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council,Hospital Virgen de la Arrixaca
(författare)
-
Gunter, MarcAarhus University
(författare)
-
Kaaks, RudolfGerman Cancer Research Centre
(författare)
-
Key, Timothy J.University of Oxford
(författare)
-
Khaw, Kay-TeeUniversity of Cambridge
(författare)
-
Kuehn, TilmanGerman Cancer Research Centre
(författare)
-
Melander, OlleLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)endo-ome
(författare)
-
Molina-Portillo, ElenaCIBER Epidemiology and Public Health (CIBERESP),University of Granada
(författare)
-
Nilsson, Peter M.University of Cambridge(Swepub:lu)medf-pni
(författare)
-
Olsen, AnjaDanish Cancer Society
(författare)
-
Overvad, KimAarhus University Hospital,Aarhus University
(författare)
-
Palli, DomenicoCancer Research and Prevention Institute (ISPO)
(författare)
-
Panico, SalvatoreUniversity of Naples Federico II
(författare)
-
Rolandsson, OlovUmeå University,Umeå universitet,Allmänmedicin(Swepub:umu)olro0005
(författare)
-
Sieri, SabinaIstituto Nazionale dei Tumori
(författare)
-
Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin
(författare)
-
Slimani, NadiaInternational Agency for Research on Cancer, World Health Organization
(författare)
-
Spijkerman, Annemieke M. W.National Institute for Public Health and the Environment (RIVM)
(författare)
-
Tjønneland, AnneDanish Cancer Society
(författare)
-
Tumino, RosarioCivic and M.P Arezzo Hospital
(författare)
-
van der Schouw, Yvonne T.University Medical Center Utrecht
(författare)
-
Langenberg, ClaudiaUniversity of Cambridge
(författare)
-
Riboli, ElioImperial College London
(författare)
-
Forouhi, Nita G.University of Cambridge
(författare)
-
Wareham, Nick J.University of Cambridge
(författare)
-
University of CambridgeMRC Human Nutrition Research
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:PLoS Medicine: Public Library Science14:101549-12771549-1676
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Imamura, Fumiaki
-
Sharp, Stephen J ...
-
Koulman, Albert
-
Schulze, Matthia ...
-
Kröger, Janine
-
Griffin, Julian ...
-
visa fler...
-
Huerta, José M.
-
Guevara, Marcela
-
Sluijs, Ivonne
-
Agudo, Antonio
-
Ardanaz, Eva
-
Balkau, Beverley
-
Boeing, Heiner
-
Chajes, Veroniqu ...
-
Dahm, Christina ...
-
Dow, Courtney
-
Fagherazzi, Guy
-
Feskens, Edith J ...
-
Franks, Paul W.
-
Gavrila, Diana
-
Gunter, Marc
-
Kaaks, Rudolf
-
Key, Timothy J.
-
Khaw, Kay-Tee
-
Kuehn, Tilman
-
Melander, Olle
-
Molina-Portillo, ...
-
Nilsson, Peter M ...
-
Olsen, Anja
-
Overvad, Kim
-
Palli, Domenico
-
Panico, Salvator ...
-
Rolandsson, Olov
-
Sieri, Sabina
-
Sacerdote, Carlo ...
-
Slimani, Nadia
-
Spijkerman, Anne ...
-
Tjønneland, Anne
-
Tumino, Rosario
-
van der Schouw, ...
-
Langenberg, Clau ...
-
Riboli, Elio
-
Forouhi, Nita G.
-
Wareham, Nick J.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Näringslära
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
PLoS Medicine
- Av lärosätet
-
Umeå universitet
-
Lunds universitet