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  • Eklöf, Vincy,1984-Umeå universitet,Patologi (author)

Cancer-associated fecal microbial markers in colorectal cancer detection

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-09-06
  • John Wiley & Sons,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-142380
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142380URI
  • https://doi.org/10.1002/ijc.31011DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Colorectal cancer (CRC) is the second most common cause of cancer death in the western world. An effective screening program leading to early detection of disease would severely reduce the mortality of CRC. Alterations in the gut microbiota have been linked to CRC, but the potential of microbial markers for use in CRC screening has been largely unstudied. We used a nested case-control study of 238 study subjects to explore the use of microbial markers for clbA+ bacteria harboring the pks pathogenicity island, afa-C+ diffusely adherent Escherichia coli harboring the afa-1 operon, and Fusobacterium nucleatum in stool as potential screening markers for CRC. We found that individual markers for clbA+ bacteria and F. nucleatum were more abundant in stool of patients with CRC, and could predict cancer with a relatively high specificity (81.5% and 76.9%, respectively) and with a sensitivity of 56.4% and 69.2%, respectively. In a combined test of clbA+ bacteria and F. nucleatum, CRC was detected with a specificity of 63.1% and a sensitivity of 84.6%. Our findings support a potential value of microbial factors in stool as putative noninvasive biomarkers for CRC detection. We propose that microbial markers may represent an important future screening strategy for CRC, selecting patients with a "high-risk" microbial pattern to other further diagnostic procedures such as colonoscopy.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Löfgren-Burström, AnnaUmeå universitet,Patologi(Swepub:umu)anlo0002 (author)
  • Zingmark, Carl,1975-Umeå universitet,Patologi(Swepub:umu)cazi0001 (author)
  • Edin, SofiaUmeå universitet,Patologi(Swepub:umu)soed0001 (author)
  • Larsson, PärUmeå universitet,Patologi(Swepub:umu)pala0006 (author)
  • Karling, PontusUmeå universitet,Medicin(Swepub:umu)peakag84 (author)
  • Alexeyev, OlegUmeå universitet,Patologi(Swepub:umu)olgalv83 (author)
  • Rutegård, Jörgen,1948-Umeå universitet,Kirurgi(Swepub:umu)jaru0001 (author)
  • Wikberg, Maria LUmeå universitet,Patologi(Swepub:umu)mahe0061 (author)
  • Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001 (author)
  • Umeå universitetPatologi (creator_code:org_t)

Related titles

  • In:International Journal of Cancer: John Wiley & Sons141:12, s. 2528-25360020-71361097-0215

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