Respiratory syncytial virus in adults with severe acute respiratory illness in a high HIV prevalence setting

Background: There are limited data on the epidemiology of respiratory syncytial virus (RSV) illness in HIV-infected adults or the elderly in Africa. We studied the epidemiology of RSV-associated severe acute respiratory illness (SARI) hospitalizations in adults in South Africa from 2009 through 2013. Methods: Individuals admitted to sentinel surveillance hospitals were investigated by respiratory tract swabs for RSV, using a multiplex real-time polymerase chain reaction assay. The incidence of RSV-associated SARI was calculated for the one site with population denominators. Results: Of 7796 participants investigated, 329 (4%) tested positive for RSV. On multivariable analysis, HIV-infected individuals with RSV-associated SARI had greater odds of being in the age groups 18-44 and 45-64 years (odd ratios (OR) 26.3; 95% confidence interval (CI) 6.2-112.1 and OR 11.4; 95% CI 2.6-50.0) compared with those >= 65 years and being female (OR 2.7; 95% CI 1.4-5.4). The relative risk of hospitalization with RSV-associated SARI was 12-18 times higher in HIV infected individual compared to that of HIV-uninfected. Conclusion: The incidence of RSV-associated SARI was higher in HIV-infected individuals and those aged 65 years and older. Further studies are warranted to describe the disease association of RSV detected in adults with SARI.

Walaza, Sibongile (författare)
Pretorius, Marthi (författare)
Groome, Michelle (författare)
von Gottberg, Anne (författare)
Wolter, Nicole (författare)
Haffejee, Sumayya (författare)
Variava, Ebrahim (författare)
Cohen, Adam L. (författare)
Tempia, Stefano (författare)
Kahn, KathleenUmeå universitet,Epidemiologi och global hälsa,MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network Accra, Ghana(Swepub:umu)kaka0045 (författare)
Dawood, Halima (författare)
Venter, Marietjie (författare)
Cohen, Cheryl (författare)
Madhi, Shabir A. (författare)
Umeå universitetEpidemiologi och global hälsa (creator_code:org_t)

Ingår i:Journal of Infection: Saunders Elsevier75:4, s. 346-3550163-44531532-2742

Av författaren/redakt...: Moyes, Jocelyn; Walaza, Sibongil ...; Pretorius, Marth ...; Groome, Michelle; von Gottberg, An ...; Wolter, Nicole; visa fler...; Haffejee, Sumayy ...; Variava, Ebrahim; Cohen, Adam L.; Tempia, Stefano; Kahn, Kathleen; Dawood, Halima; Venter, Marietji ...; Cohen, Cheryl; Madhi, Shabir A.; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.