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One-carbon metaboli...
One-carbon metabolite ratios as functional B-vitamin markers and in relation to colorectal cancer risk
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- Gylling, Björn, 1978- (författare)
- Umeå universitet,Patologi
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- Myte, Robin (författare)
- Umeå universitet,Onkologi
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- Ulvik, Arve (författare)
- Bevital AS, Laboratory building, Bergen, Norway
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- Ueland, Per Magne (författare)
- Department of Clinical Science, University of Bergen and Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
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- Midttun, Øivind (författare)
- Bevital AS, Laboratory building, Bergen, Norway
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- Schneede, Jørn (författare)
- Umeå universitet,Farmakologi
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Näringsforskning
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- Häggström, Jenny, 1980- (författare)
- Umeå universitet,Statistik
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- Johansson, Ingegerd (författare)
- Umeå universitet,Institutionen för odontologi
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- van Guelpen, Bethany (författare)
- Umeå universitet,Onkologi
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- Palmqvist, Richard (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2018-12-07
- 2019
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 144:5, s. 947-956
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Ämnesord
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- Background: One-carbon metabolism biomarker are easily measured in plasma, but analyzing them one at a time in relation to disease does not take into account the interdependence of the many factors involved. The relative dynamics of major one-carbon metabolism branches can be assessed by relating the functional B-vitamin marker total homocysteine (tHcy) to transsulfuration (total cysteine) and methylation (creatinine) outputs.Objective: We validated the ratios of tHcy to total cysteine (Hcy:Cys), tHcy to creatinine (Hcy:Cre), and tHcy to cysteine to creatinine (Hcy:Cys:Cre) as functional markers of B-vitamin status. We also calculated the associations of these ratios to colorectal cancer (CRC) risk.Design: The relative contribution of potential confounders to the variance of the ratio-based B-vitamin markers was calculated by linear regression in a nested case-control study of 613 CRC cases and 1211 matched controls. Total B-vitamin status was represented by a summary score comprising Z-standardized plasma concentrations of folate, cobalamin, betaine, pyridoxal 5´-phosphate, and riboflavin. Associations with CRC risk were estimated using conditional logistic regression.Results: The ratio-based B-vitamin markers all outperformed tHcy as markers of total B-vitamin status, in both CRC cases and controls. Associations with CRC risk were similar for the ratio-based B-vitamin markers and total B-vitamin status (approximately 25% lower risk for high versus low B-vitamin status).Conclusions: Ratio-based B-vitamin markers were good predictors of total B-vitamin status, and displayed similar associations with CRC risk. Since tHcy and creatinine are routinely clinically analyzed, Hcy:Cre could be easily implemented in clinical practice to aid interpretation of tHcy results.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Biomarkers
- colorectal cancer
- metabolite ratios
- B-vitamins
- one-carbon metabolism
- Cancer Epidemiology
- cancerepidemiologi
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- ref (ämneskategori)
- art (ämneskategori)
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Gylling, Björn, ...
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Myte, Robin
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Ulvik, Arve
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Ueland, Per Magn ...
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Midttun, Øivind
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Schneede, Jørn
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Hallmans, Göran, ...
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Häggström, Jenny ...
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Johansson, Ingeg ...
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van Guelpen, Bet ...
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Palmqvist, Richa ...
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