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Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets

Best, Myron G. (author)
Sol, Nik (author)
't Veld, Sjors G. J. G. In (author)
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Vancura, Adrienne (author)
Muller, Mirte (author)
Niemeijer, Anna-Larissa N. (author)
Fejes, Aniko V. (author)
Tjon Kon Fat, Lee-Ann (author)
Umeå universitet,Onkologi
't Veld, Anna E. Huis In (author)
Leurs, Cyra (author)
Le Large, Tessa Y. (author)
Meijer, Laura L. (author)
Kooi, Irsan E. (author)
Rustenburg, Francois (author)
Schellen, Pepijn (author)
Verschueren, Heleen (author)
Post, Edward (author)
Wedekind, Laurine E. (author)
Bracht, Jillian (author)
Esenkbrink, Michelle (author)
Wils, Leon (author)
Favaro, Francesca (author)
Schoonhoven, Jilian D. (author)
Tannous, Jihane (author)
Meijers-Heijboer, Hanne (author)
Kazemier, Geert (author)
Giovannetti, Elisa (author)
Reijneveld, Jaap C. (author)
Idema, Sander (author)
Killestein, Joep (author)
Heger, Michal (author)
de Jager, Saskia C. (author)
Urbanus, Rolf T. (author)
Hoefer, Imo E. (author)
Pasterkamp, Gerard (author)
Mannhalter, Christine (author)
Gomez-Arroyo, Jose (author)
Bogaard, Harm-Jan (author)
Noske, David P. (author)
Vandertop, W. Peter (author)
van den Broek, Daan (author)
Ylstra, Bauke (author)
Nilsson, Jonas A. (author)
Umeå universitet,Onkologi,Vrije Univ Amsterdam Med Ctr, Canc Ctr Amsterdam, Dept Neurosurg, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
Wesseling, Pieter (author)
Karachaliou, Niki (author)
Rosell, Rafael (author)
Lee-Lewandrowski, Elizabeth (author)
Lewandrowski, Kent B. (author)
Tannous, Bakhos A. (author)
de Langen, Adrianus J. (author)
Smit, Egbert F. (author)
van den Heuvel, Michel M. (author)
Wurdinger, Thomas (author)
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 (creator_code:org_t)
Elsevier, 2017
2017
English.
In: Cancer Cell. - : Elsevier. - 1535-6108 .- 1878-3686. ; 32:2, s. 238-252
Related links:
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94; 95% CI, 0.92-0.96; p < 0.001; n = 106 early-stage validation cohort, accuracy, 81%; AUC, 0.89; 95% CI, 0.83-0.95; p < 0.001), independent of age of the individuals, smoking habits, whole-blood storage time, and various inflammatory conditions. PSO enabled selection of gene panels to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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