Search: id:"swepub:oai:DiVA.org:umu-142974" >
Thiazolino 2-pyrido...
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Good, James A. D.Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)
(author)
Thiazolino 2-pyridone amide isosteres as inhibitors of Chlamydia trachomatis infectivity
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-11-03
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American Chemical Society (ACS),2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-142974
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142974URI
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https://doi.org/10.1021/acs.jmedchem.7b00716DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Chlamydia trachomatis is a global health burden due to its prevalence as a sexually transmitted disease and as the causative agent of the eye infection trachoma. We recently discovered 3-amido thiazolino 2-pyridones which attenuated C. trachomatis infectivity without affecting host cell or commensal bacteria viability. We present here the synthesis and evaluation of nonhydrolyzable amide isosteres based on this class, leading to highly potent 1,2,3-triazole based infectivity inhibitors (EC50 ≤ 20 nM).
Subject headings and genre
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Kulén, MartinaUmeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)(Swepub:umu)maku0042
(author)
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Silver, JimUmeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)(Swepub:umu)jiisir01
(author)
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Krishnan, K. SyamUmeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)(Swepub:umu)sykr0001
(author)
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Bahnan, WaelUmeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)waba0006
(author)
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Núñez-Otero, CarlosUmeå universitet,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för klinisk mikrobiologi(Swepub:umu)canu0006
(author)
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Nilsson, IngelaUmeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)inni0005
(author)
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Wede, EmmaUmeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)anoema01
(author)
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de Groot, EsmeeUmeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Molekylär Infektionsmedicin, Sverige (MIMS)
(author)
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Gylfe, ÅsaUmeå universitet,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för klinisk mikrobiologi(Swepub:umu)asagye91
(author)
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Bergström, SvenUmeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)svbe0001
(author)
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Almqvist, FredrikUmeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)(Swepub:umu)fral0001
(author)
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Umeå universitetKemiska institutionen
(creator_code:org_t)
Related titles
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In:Journal of Medicinal Chemistry: American Chemical Society (ACS)60:22, s. 9393-93990022-26231520-4804
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Good, James A. D ...
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Kulén, Martina
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Silver, Jim
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Krishnan, K. Sya ...
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Bahnan, Wael
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Núñez-Otero, Car ...
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Nilsson, Ingela
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Wede, Emma
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de Groot, Esmee
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Gylfe, Åsa
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Bergström, Sven
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Almqvist, Fredri ...
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- MEDICAL AND HEALTH SCIENCES
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Umeå University