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Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality multilocation analysis in 398 cities.
- E-article/E-chapterEnglish2021
Publisher, publication year, extent ...
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BMJ Publishing Group Ltd,2021
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LIBRIS-ID:fs9n2spwcdx36mxx
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http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181867uri
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urn:nbn:se:umu:diva-181867urn
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10.1136/bmj.n534doi
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Published
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EU, Horisont 2020 [820655]
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gratis
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OBJECTIVE: To evaluate the short term associations between nitrogen dioxide (NO 2 ) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. DESIGN: Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. SETTING: 398 cities in 22 low to high income countries/regions. MAIN OUTCOME MEASURES: Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018. RESULTS: On average, a 10 μg/m 3 increase in NO 2 concentration on lag 1 day (previous day) was associated with 0.46% (95% confidence interval 0.36% to 0.57%), 0.37% (0.22% to 0.51%), and 0.47% (0.21% to 0.72%) increases in total, cardiovascular, and respiratory mortality, respectively. These associations remained robust after adjusting for co-pollutants (particulate matter with aerodynamic diameter ≤10 μm or ≤2.5 μm (PM 10 and PM 2.5 , respectively), ozone, sulfur dioxide, and carbon monoxide). The pooled concentration-response curves for all three causes were almost linear without discernible thresholds. The proportion of deaths attributable to NO 2 concentration above the counterfactual zero level was 1.23% (95% confidence interval 0.96% to 1.51%) across the 398 cities. CONCLUSIONS: This multilocation study provides key evidence on the independent and linear associations between short term exposure to NO 2 and increased risk of total, cardiovascular, and respiratory mortality, suggesting that health benefits would be achieved by tightening the guidelines and regulatory limits of NO 2 .
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Liu, Cong
(author)
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Chen, Renjie
(author)
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Sera, Francesco
(author)
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Vicedo-Cabrera, Ana Maria
(author)
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Milojevic, Ai
(author)
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Guo, Yuming
(author)
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Tong, Shilu
(author)
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Coelho, Micheline de Sousa Zanotti Stagliorio
(author)
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Saldiva, Paulo Hilario Nascimento
(author)
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Lavigne, Eric
(author)
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Correa, Patricia Matus
(author)
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Ortega, Nicolas Valdes
(author)
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Osorio Garcia, Samuel
(author)
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Kyselý, Jan
(author)
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Urban, Aleš
(author)
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Orru, Hans
(author)
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Maasikmets, Marek
(author)
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Jaakkola, Jouni J. K.
(author)
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Ryti, Niilo
(author)
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Huber, Veronika
(author)
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Schneider, Alexandra
(author)
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Katsouyanni, Klea
(author)
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Analitis, Antonis
(author)
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Hashizume, Masahiro
(author)
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Honda, Yasushi
(author)
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Ng, Chris Fook Sheng
(author)
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Nunes, Baltazar
(author)
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Teixeira, João Paulo
(author)
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Holobaca, Iulian Horia
(author)
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Fratianni, Simona
(author)
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Kim, Ho
(author)
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Tobias, Aurelio
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Íñiguez, Carmen
(author)
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Forsberg, Bertil
(author)
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Åström, Christofer,1983-
(author)
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Ragettli, Martina S.
(author)
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Guo, Yue-Liang Leon
(author)
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Pan, Shih-Chun
(author)
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Li, Shanshan
(author)
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Bell, Michelle L.
(author)
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Zanobetti, Antonella
(author)
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Schwartz, Joel
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Wu, Tangchun
(author)
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Gasparrini, Antonio
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Kan, Haidong
(author)
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Umeå universitetMedicinska fakulteten
(publisher)
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