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  • Meng, Xia (author)

Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality multilocation analysis in 398 cities.

  • E-article/E-chapterEnglish2021

Publisher, publication year, extent ...

  • BMJ Publishing Group Ltd,2021

Numbers

  • LIBRIS-ID:fs9n2spwcdx36mxx
  • http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181867uri
  • urn:nbn:se:umu:diva-181867urn
  • 10.1136/bmj.n534doi

Supplementary language notes

  • Language:English

Part of subdatabase

Notes

  • Published
  • EU, Horisont 2020 [820655]
  • gratis
  • OBJECTIVE: To evaluate the short term associations between nitrogen dioxide (NO 2 ) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. DESIGN: Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. SETTING: 398 cities in 22 low to high income countries/regions. MAIN OUTCOME MEASURES: Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018. RESULTS: On average, a 10 μg/m 3 increase in NO 2 concentration on lag 1 day (previous day) was associated with 0.46% (95% confidence interval 0.36% to 0.57%), 0.37% (0.22% to 0.51%), and 0.47% (0.21% to 0.72%) increases in total, cardiovascular, and respiratory mortality, respectively. These associations remained robust after adjusting for co-pollutants (particulate matter with aerodynamic diameter ≤10 μm or ≤2.5 μm (PM 10 and PM 2.5 , respectively), ozone, sulfur dioxide, and carbon monoxide). The pooled concentration-response curves for all three causes were almost linear without discernible thresholds. The proportion of deaths attributable to NO 2 concentration above the counterfactual zero level was 1.23% (95% confidence interval 0.96% to 1.51%) across the 398 cities. CONCLUSIONS: This multilocation study provides key evidence on the independent and linear associations between short term exposure to NO 2 and increased risk of total, cardiovascular, and respiratory mortality, suggesting that health benefits would be achieved by tightening the guidelines and regulatory limits of NO 2 .

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Liu, Cong (author)
  • Chen, Renjie (author)
  • Sera, Francesco (author)
  • Vicedo-Cabrera, Ana Maria (author)
  • Milojevic, Ai (author)
  • Guo, Yuming (author)
  • Tong, Shilu (author)
  • Coelho, Micheline de Sousa Zanotti Stagliorio (author)
  • Saldiva, Paulo Hilario Nascimento (author)
  • Lavigne, Eric (author)
  • Correa, Patricia Matus (author)
  • Ortega, Nicolas Valdes (author)
  • Osorio Garcia, Samuel (author)
  • Kyselý, Jan (author)
  • Urban, Aleš (author)
  • Orru, Hans (author)
  • Maasikmets, Marek (author)
  • Jaakkola, Jouni J. K. (author)
  • Ryti, Niilo (author)
  • Huber, Veronika (author)
  • Schneider, Alexandra (author)
  • Katsouyanni, Klea (author)
  • Analitis, Antonis (author)
  • Hashizume, Masahiro (author)
  • Honda, Yasushi (author)
  • Ng, Chris Fook Sheng (author)
  • Nunes, Baltazar (author)
  • Teixeira, João Paulo (author)
  • Holobaca, Iulian Horia (author)
  • Fratianni, Simona (author)
  • Kim, Ho (author)
  • Tobias, Aurelio (author)
  • Íñiguez, Carmen (author)
  • Forsberg, Bertil (author)
  • Åström, Christofer,1983- (author)
  • Ragettli, Martina S. (author)
  • Guo, Yue-Liang Leon (author)
  • Pan, Shih-Chun (author)
  • Li, Shanshan (author)
  • Bell, Michelle L. (author)
  • Zanobetti, Antonella (author)
  • Schwartz, Joel (author)
  • Wu, Tangchun (author)
  • Gasparrini, Antonio (author)
  • Kan, Haidong (author)
  • Umeå universitetMedicinska fakulteten (publisher)

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  • Part of/supplement to:channel record
  • In:BMJ. British Medical Journal372

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