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Physical activity, mediating factors and risk of colon cancer : insights into adiposity and circulating biomarkers from the EPIC cohort
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Aleksandrova, Krasimira (author)
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Jenab, Mazda (author)
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Leitzmann, Michael (author)
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Bueno-de-Mesquita, Bas (author)
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Kaaks, Rudolf (author)
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Trichopoulou, Antonia (author)
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Bamia, Christina (author)
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Lagiou, Pagona (author)
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Rinaldi, Sabina (author)
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Freisling, Heinz (author)
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Carayol, Marion (author)
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Pischon, Tobias (author)
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Drogan, Dagmar (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Jakszyn, Paula (author)
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Overvad, Kim (author)
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Dahm, Christina C. (author)
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Tjonneland, Anne (author)
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Bouton-Ruault, Marie-Christine (author)
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Kuehn, Tilman (author)
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Peppa, Eleni (author)
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Valanou, Elissavet (author)
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La Vecchia, Carlo (author)
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Palli, Domenico (author)
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Panico, Salvatore (author)
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Sacerdote, Carlotta (author)
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Agnoli, Claudia (author)
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Tumino, Rosario (author)
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May, Anne (author)
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van Vulpen, Jonna (author)
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Borch, Kristin Benjaminsen (author)
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Oyeyemi, Sunday Oluwafemi (author)
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Ramon Quiros, J. (author)
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Bonet, Catalina (author)
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Sanchez, Maria-Jose (author)
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Dorronsoro, Miren (author)
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Navarro, Carmen (author)
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Barricarte, Aurelio (author)
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- van Guelpen, Bethany (author)
- Umeå universitet,Onkologi
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- Wennberg, Patrik (author)
- Umeå universitet,Allmänmedicin
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Key, Timothy J. (author)
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Khaw, Kay-Tee (author)
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Wareham, Nicholas (author)
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Assi, Nada (author)
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Ward, Heather A. (author)
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Aune, Dagfinn (author)
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Riboli, Elio (author)
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Boeing, Heiner (author)
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(creator_code:org_t)
- 2017-09-05
- 2017
- English.
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In: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 46:6, s. 1823-1835
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline. High physical activity was associated with a lower risk of colon cancer: relative risk a parts per thousand91 MET-h/week vs < 91 MET-h/week = 0.75 [95% confidence interval (CI): 0.57 to 0.96]. In mediation analyses, this association was accounted for by waist circumference: proportion explained effect (PEE) = 17%; CI: 4% to 52%; and the biomarkers soluble leptin receptor (sOB-R): PEE = 15%; 95% CI: 1% to 50% and 5-hydroxyvitamin D (25[OH]D): PEE = 30%; 95% CI: 12% to 88%. In combination, these factors explained 45% (95% CI: 20% to 125%) of the association. Beyond waist circumference, sOB-R and 25[OH]D additionally explained 10% (95% CI: 1%; 56%) and 23% (95% CI: 6%; 111%) of the association, respectively. Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Physical activity
- colon cancer
- mediating factors
- adiposity
- biomarkers
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Aleksandrova, Kr ...
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Jenab, Mazda
-
Leitzmann, Micha ...
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Bueno-de-Mesquit ...
-
Kaaks, Rudolf
-
Trichopoulou, An ...
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show more...
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Bamia, Christina
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Lagiou, Pagona
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Rinaldi, Sabina
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Freisling, Heinz
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Carayol, Marion
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Pischon, Tobias
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Drogan, Dagmar
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Weiderpass, Elis ...
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Jakszyn, Paula
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Overvad, Kim
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Dahm, Christina ...
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Tjonneland, Anne
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Bouton-Ruault, M ...
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Kuehn, Tilman
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Peppa, Eleni
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Valanou, Elissav ...
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La Vecchia, Carl ...
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Palli, Domenico
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Panico, Salvator ...
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Sacerdote, Carlo ...
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Agnoli, Claudia
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Tumino, Rosario
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May, Anne
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van Vulpen, Jonn ...
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Borch, Kristin B ...
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Oyeyemi, Sunday ...
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Ramon Quiros, J.
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Bonet, Catalina
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Sanchez, Maria-J ...
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Dorronsoro, Mire ...
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Navarro, Carmen
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Barricarte, Aure ...
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van Guelpen, Bet ...
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Wennberg, Patrik
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Key, Timothy J.
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Assi, Nada
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Ward, Heather A.
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Aune, Dagfinn
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Riboli, Elio
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Boeing, Heiner
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Karolinska Institutet