Health Status Perspectives in Amyotrophic Lateral Sclerosis

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Pinto, SusanaUmeå universitet,Klinisk neurovetenskap,Institute of Physiology, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal (author)

Health Status Perspectives in Amyotrophic Lateral Sclerosis

Article/chapterEnglish2017

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2017-10-31
S. Karger,2017
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LIBRIS-ID:oai:DiVA.org:umu-143680
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143680URI
https://doi.org/10.1159/000480638DOI

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Language:English
Summary in:English

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Background/Aims: The global perception of the health status (HS) of amyotrophic lateral sclerosis (ALS) patients before the initial diagnosis has not been addressed previously. Methods: We recorded the following at the first visit, before diagnostic information: (1) visual analog scale (VAS) of the EQ-5D; (2) the revised ALS functional rating scale (ALSFRSR), bulbar (ALSFRSb), upper limb (ALSFRSul), lower limb (ALSFRSll), and respiratory (RofALSFRS-R) subscores; and (3) forced and slow vital capacities. Correlations were tested by the Pearson correlation test. Variables were compared between groups defined by the VAS median value. p < 0.05 was considered significant. Results: Of the 156 patients included in the study (91 spinal-onset, 49 bulbar-onset, 16 axial/respiratory- onset; 95 men; mean onset age 63.9 +/- 13 years; mean disease duration 18.4 +/- 26.5 months), HS VAS was significantly lower in spinal-onset patients (p = 0.047), and particularly in spinal-onset women (p = 0.027). Disease duration had no influence. HS VAS was moderately correlated with ALS-FRS, ALSFRSul and ALSFRSll (0.4 < r < 0.5, p < 0.01), weakly correlated with RofALSFRS-R in the whole population (r = 0.171, p < 0.05), and not correlated with ALSFRSb or the respiratory tests. ALSFRSb was similar between groups defined by the HS VAS median value, but the other scores were significantly lower for poorer HS values. Conclusion: HS before diagnosis is mostly dependent on the perception of upper and lower limb function. A tool tailored to evaluate HS in bulbar-onset patients should be developed.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Amyotrophic lateral sclerosis
Quality of life
Health status
Health status visual analog scale
ALS functional rating scale

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de Carvalho, Mamede (author)
Umeå universitetKlinisk neurovetenskap (creator_code:org_t)

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In:Neurodegenerative Diseases: S. Karger17:6, s. 323-3291660-28541660-2862

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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