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Treatment for neova...
Treatment for neovascular age-related macular degeneration in Sweden : outcomes at seven years in the Swedish Macula Register
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- Westborg, Inger (författare)
- Umeå universitet,Oftalmiatrik,Umea Univ Hosp, Dept Clin Sci, Umea, Sweden.,Norrland University Hospital
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- Granstam, Elisabet, 1963- (författare)
- Uppsala University,Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Rosso, Aldana (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups
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- Albrecht, Susanne (författare)
- Blekinge Hosp, Register Ctr South, Karlskrona, Sweden.,Blekinge Hospital
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- Karlsson, Niklas (författare)
- Orebro Univ Hosp, Dept Ophthalmol, Orebro, Sweden.,Örebro University Hospital
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- Lövestam-Adrian, Monica (författare)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2017-08-21
- 2017
- Engelska.
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Ingår i: Acta Ophthalmologica. - : Wiley. - 1755-375X .- 1755-3768. ; 95:8, s. 787-795
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http://dx.doi.org/10...
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Abstract
Ämnesord
Stäng
- Purpose: To present Swedish Macula Register (SMR) data regarding treatment of neovascular age-related macular degeneration (AMD) in clinical practice since 2008.Methods: A retrospective register-based study was conducted. Evaluation of baseline demographics, visual outcome and number of injections during this period is presented.Results: Mean age at diagnosis was 79 ± (SD) 8 years; 65% were female. The proportion of patients with <2 months' duration of symptoms increased from 26% in 2008 to 41% in 2014 (p = 0.001). Mean visual acuity (VA) at baseline increased from 54.3 ± 15.0 early treatment diabetic retinopathy study (ETDRS) letters in 2008 to 57.8 ± 15.6 letters in 2014 (CI95 2.6; 4.3; p < 0.001). Mean VA after 1 year of treatment increased from 57.8 ± 17.7 ETDRS letters for patients who started the treatment in 2008 to 62.8 ± 16.4 ETDRS letters in patients starting treatment in 2014 (CI95 2.67; 4.64; p < 0.001). During all study years, the proportion of patients with an improvement in VA of between 5 and 15 letters was around 30%, while 14% had VA improvement of more than 15 letters. The mean number of injections during the first treatment year increased from 4.3 ± 1.9 in 2008 to 5.9 ± 2.9 in 2014 (CI95 1.40; 1.67; p < 0.001). Seven-year follow-up of 322 eyes showed a mean change of -1 letters from baseline, with a mean of 21 injections for the entire period.Conclusion: The duration of symptoms before treatment decreased, while VA at baseline and after 1 year of treatment increased over the years and so did the number of injections. Long-term follow-up demonstrated stable VA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- ETDRS
- Swedish Macula Register
- age-related macular degeneration
- anti-VEGF
- anti-vascular endothelial growth factor
- neovascular AMD
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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