id:"swepub:oai:DiVA.org:umu-144509"
Search: id:"swepub:oai:DiVA.org:umu-144509" > Traumatic brain inj...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Nordström, AnnaUmeå universitet,Yrkes- och miljömedicin,School of Sports Science, UiT The Arctic University of Norway, Tromsø, Norway. (author)
Traumatic brain injury and the risk of dementia diagnosis : A nationwide cohort study
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2018-01-30
- Public Library of Science,2018
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-144509
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144509URI
- https://doi.org/10.1371/journal.pmed.1002496DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- BACKGROUND: Traumatic brain injury (TBI) has been associated with dementia. The questions of whether the risk of dementia decreases over time after TBI, whether it is similar for different TBI types, and whether it is influenced by familial aggregation are not well studied.METHODS AND FINDINGS: The cohort considered for inclusion comprised all individuals in Sweden aged ≥50 years on December 31, 2005 (n = 3,329,360). Diagnoses of dementia and TBI were tracked through nationwide databases from 1964 until December 31, 2012. In a first cohort, individuals diagnosed with TBI (n = 164,334) were matched with up to two controls. A second cohort consisted of subjects diagnosed with dementia during follow-up (n = 136,233) matched with up to two controls. A third cohort consisted of 46,970 full sibling pairs with discordant TBI status. During a mean follow-up period of 15.3 (range, 0-49) years, 21,963 individuals in the first cohort (6.3% with TBI, 3.6% without TBI) were diagnosed with dementia (adjusted odds ratio [OR], 1.81; 95% confidence interval [CI], 1.75-1.86). The association was strongest in the first year after TBI (OR, 3.52; 95% CI, 3.23-3.84), but the risk remained significant >30 years (OR, 1.25; 95% CI, 1.11-1.41). Single mild TBI showed a weaker association with dementia (OR, 1.63; 95% CI, 1.57-1.70) than did more severe TBI (OR, 2.06; 95% CI, 1.95-2.19) and multiple TBIs (OR, 2.81; 95% CI, 2.51-3.15). These results were in general confirmed in the nested case-control cohort. TBI was also associated with an increased risk of dementia diagnosis in sibling pairs with discordant TBI status (OR, 1.89; 95% CI, 1.62-2.21). A main limitation of the present study is the observational design. Thus, no causal inferences can be made based on the associations found.CONCLUSIONS: The risk of dementia diagnosis decreased over time after TBI, but it was still evident >30 years after the trauma. The association was stronger for more severe TBI and multiple TBIs, and it persisted after adjustment for familial factors.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Nordström, PeterUmeå universitet,Geriatrik(Swepub:umu)peno0014 (author)
- Umeå universitetYrkes- och miljömedicin (creator_code:org_t)
Related titles
- In:PLoS Medicine: Public Library of Science15:11549-12771549-1676
Internet link
- https://doi.org/10.1371/journal.pmed.1002496Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1180281/FULLTEXT01.pdffulltext:print
- https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002496&type=printable
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144509
- https://doi.org/10.1371/journal.pmed.1002496
Find in a library
- PLoS Medicine (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Nordström, Anna
- Nordström, Peter
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Geriatrics
- Articles in the publication
- PLoS Medicine
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
