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Ovarian cancer earl...
Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels : Results from the EPIC cohort
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- Fortner, Renée T. (författare)
- German Cancer Research Centre
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- Schock, Helena (författare)
- German Cancer Research Centre
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- Le Cornet, Charlotte (författare)
- German Cancer Research Centre
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- Hüsing, Anika (författare)
- German Cancer Research Centre
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- Vitonis, Allison F. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Johnson, Theron S. (författare)
- German Cancer Research Centre,Istituto Nazionale dei Tumori
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- Fichorova, Raina N. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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- Fashemi, Titilayo (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Yamamoto, Hidemi S. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Hansen, Louise (författare)
- Danish Cancer Society
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- Overvad, Kim (författare)
- Aarhus University
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- Boutron-Ruault, Marie-Christine (författare)
- Stabilite genetique et oncogenese,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)
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- Kvaskoff, Marina (författare)
- Stabilite genetique et oncogenese,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)
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- Severi, Gianluca (författare)
- Centre for Research in Epidemiology and Population Health (CESP),Human Genetics Foundation (HuGeF),University of Paris-Saclay,Stabilite genetique et oncogenese
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Papatesta, Eleni-Maria (författare)
- Hellenic Health Foundation, Athens
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- La Vecchia, Carlo (författare)
- Hellenic Health Foundation, Athens,University of Milan
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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Sieri, Sabina (författare)
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Mattiello, Amalia (författare)
- University of Naples Federico II
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- Onland-Moret, N. Charlotte (författare)
- University Medical Center Utrecht
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- Peeters, Petra H. (författare)
- University Medical Center Utrecht,Imperial College London
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- Bueno-de-Mesquita, H. B(as) (författare)
- National Institute for Public Health and the Environment (RIVM),Imperial College London
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Folkhälsan Research Center
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- Quirós, J. Ramón (författare)
- Public Health Directorate
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- Duell, Eric J. (författare)
- Catalan Institute of Oncology
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- Sánchez, Maria-Jose (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Navarro, Carmen (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Larrañaga, Nerea (författare)
- Public Health Division of Gipuzkoa,CIBER Epidemiology and Public Health (CIBERESP)
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- Nodin, Björn (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jirström, Karin (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Idahl, Annika (författare)
- Umeå University,Umeå universitet,Obstetrik och gynekologi,Näringsforskning
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- Lundin, Eva (författare)
- Umeå University,Umeå universitet,Patologi
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- Travis, Ruth C. (författare)
- University of Oxford
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- Gunter, Marc (författare)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization
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- Dossus, Laure (författare)
- International Agency for Research on Cancer, World Health Organization
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- Merritt, Melissa A. (författare)
- Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Terry, Kathryn L. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Cramer, Daniel W. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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(creator_code:org_t)
- 2017-12-11
- 2018
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 142:7, s. 1355-1360
- Relaterad länk:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases. We investigated these objectives using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to four matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2-year lag-time intervals were calculated using conditional logistic regression calibrated toward the absolute risk estimates from a pre-existing epidemiological risk model as an offset-variable. Anti-CA125 levels alone did not discriminate cases from controls. For cases diagnosed <2 years after blood collection, discrimination by CA125 antigen was suggestively higher with higher anti-CA125 levels (aAUC, highest antibody tertile: 0.84 [0.76-0.92]; lowest tertile: 0.76 [0.67-0.86]; p(het)=0.06). We provide the first evidence of potentially synergistic discrimination effects of CA125 and anti-CA125 antibodies in ovarian early detection. If these findings are replicated, evaluating CA125 in the context of its antibody may improve ovarian cancer early detection. What's new? Although CA125, a mucin produced in epithelial cells, is a known marker for ovarian cancer, complementary biomarkers are necessary for reliable early cancer detection. Here, the authors examined autoantibodies against CA125 as potential pre-diagnosis markers. Although anti-CA125 levels did not discriminate between ovarian cases and controls, discrimination of CA125 differed by levels of its antibody, with the highest discrimination among women with the highest antibody levels. The authors propose that CA125 and anti-CA125 may act synergistically for ovarian cancer early detection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- ovarian cancer
- early detection markers
- CA125
- anti-CA125 antibodies
- MUC16
- autoantibodies
- anti-CA125 antibodies
- autoantibodies
- CA125
- early detection markers
- MUC16
- ovarian cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Fortner, Renée T ...
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Schock, Helena
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Le Cornet, Charl ...
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Hüsing, Anika
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Vitonis, Allison ...
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Johnson, Theron ...
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visa fler...
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Fichorova, Raina ...
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Fashemi, Titilay ...
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Yamamoto, Hidemi ...
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Tjonneland, Anne
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Hansen, Louise
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Overvad, Kim
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Boutron-Ruault, ...
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Kvaskoff, Marina
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Severi, Gianluca
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Boeing, Heiner
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Trichopoulou, An ...
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Papatesta, Eleni ...
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La Vecchia, Carl ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Sacerdote, Carlo ...
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Mattiello, Amali ...
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Onland-Moret, N. ...
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Peeters, Petra H ...
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Bueno-de-Mesquit ...
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Weiderpass, Elis ...
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Quirós, J. Ramón
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Duell, Eric J.
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Sánchez, Maria-J ...
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Navarro, Carmen
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Ardanaz, Eva
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Larrañaga, Nerea
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Nodin, Björn
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Jirström, Karin
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Idahl, Annika
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Lundin, Eva
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Khaw, Kay-Tee
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Travis, Ruth C.
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Gunter, Marc
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Johansson, Matti ...
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Dossus, Laure
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Merritt, Melissa ...
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Riboli, Elio
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Terry, Kathryn L ...
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Cramer, Daniel W ...
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Kaaks, Rudolf
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och Klinisk medicin
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och Cancer och onkol ...
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Umeå universitet
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