L773:0940 5429 OR L773:1432 5233
Sökning: L773:0940 5429 OR L773:1432 5233 > Family history of d...
- Bennet, LouiseLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Skåne University Hospital (författare)
Family history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes : a population-based cohort study
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
- 2017-12-22
- Springer Milan,2018
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:umu-146160
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146160URI
- https://doi.org/10.1007/s00592-017-1088-5DOI
- https://lup.lub.lu.se/record/b47cd931-fea5-4f77-878a-3fcd241acaa3URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Aims Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of rst-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described. Methods Citizens of Malmö, Sweden, aged 30–75 years born in Iraq or Sweden were invited to participate in this population- based study. Insulin secretion (corrected insulin response and oral disposition index) and action (insulin sensitivity index) were assessed by oral glucose tolerance tests.Results In total, 45.7% of Iraqis (616/1348) and 27.4% of native Swedes (201/733) had FH in parent(s), sibling(s) or single parent and sibling, i.e., FH+. Approximately 8% of Iraqis and 0.7% of Swedes had ≥ 3 sibling(s) and parent(s) with diabetes, i.e., FH++. Irrespective of family size, prediabetes and diabetes increased with family burden (FH− 29.4%; FH+ 38.8%; FH++ 61.7%) without signi cant di erences across ethnicities. With increasing level of family burden, insulin secretion rather than insulin action decreased. Individuals with a combination of ≥ 3 siblings and parents with diabetes presented with the lowest levels of insulin secretion.Conclusions The Iraqi immigrant population often present with a strong familial burden of type 2 diabetes with the worst glycemic control and highest diabetes risk in individuals with ≥ 3 siblings and parents with diabetes. Our data show that in a population still free from diabetes familial burden in uences insulin secretion to a higher degree than insulin action and may be a logical target for intervention.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- Family history of diabetes
- Insulin action
- Insulin secretion
- Middle East
- Type 2 diabetes
- Family history of diabetes
- Insulin action
- Insulin secretion
- Middle East
- Type 2 diabetes
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Franks, Paul W.Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Diabetes and Endocrinology/Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf (författare)
- Zöller, BengtLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)medf-bzo (författare)
- Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-lgr (författare)
- Allmänmedicin och samhällsmedicinForskargrupper vid Lunds universitet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Acta Diabetologica: Springer Milan55:3, s. 233-2420940-54291432-5233
Internetlänk
- https://doi.org/10.1007/s00592-017-1088-5Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1206007/FULLTEXT01.pdffulltext:print
- https://link.springer.com/content/pdf/10.1007%2Fs00592-017-1088-5.pdf
- http://dx.doi.org/10.1007/s00592-017-1088-5FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146160
- https://doi.org/10.1007/s00592-017-1088-5
- https://lup.lub.lu.se/record/b47cd931-fea5-4f77-878a-3fcd241acaa3
Hitta mer i SwePub
- Av författaren/redakt...
- Bennet, Louise
- Franks, Paul W.
- Zöller, Bengt
- Groop, Leif
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Endokrinologi oc ...
- Artiklar i publikationen
- Acta Diabetologi ...
- Av lärosätet
- Umeå universitet
- Lunds universitet
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