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High levels of mito...
High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression
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- Tymofiyeva, Olga (författare)
- University of California System
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- Henje Blom, Eva (författare)
- Umeå University,Karolinska Institutet,Umeå universitet,Barn- och ungdomspsykiatri,Department of Psychiatry and Weill Institute for Neurosciences, University of California San Francisco, United States,University of California System
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- Ho, Tiffany C. (författare)
- Stanford University,University of California System
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visa fler...
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- Connolly, Colm G. (författare)
- University of California System
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- Lindqvist, Daniel (författare)
- Lund University,Lunds universitet,Psykiatri,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Psychiatry,Department of Clinical Sciences, Malmö,Faculty of Medicine,University of California System
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- Wolkowitz, Owen M. (författare)
- University of California System
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- Lin, Jue (författare)
- University of California System
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- LeWinn, Kaja Z. (författare)
- University of California System
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- Sacchet, Matthew D. (författare)
- Stanford University
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- Han, Laura K. M. (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Yuan, Justin P. (författare)
- University of California System
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- Bhandari, Sarina P. (författare)
- University of California System
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- Xu, Duan (författare)
- University of California System
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- Yang, Tony T. (författare)
- University of California System
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(creator_code:org_t)
- Amsterdam : Elsevier, 2018
- 2018
- Engelska.
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Ingår i: Journal of Affective Disorders. - Amsterdam : Elsevier. - 0165-0327 .- 1573-2517. ; 232, s. 283-290
- Relaterad länk:
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https://europepmc.or...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Adolescent anxiety and depression are highly prevalent psychiatric disorders that are associated with altered molecular and neurocircuit profiles. Recently, increased mitochondrial DNA copy number (mtDNA-cn) has been found to be associated with several psychopathologies in adults, especially anxiety and depression. The associations between mtDNA-cn and anxiety and depression have not, however, been investigated in adolescents. Moreover, to date there have been no studies examining associations between mtDNA-cn and brain network alterations in mood disorders in any age group.METHODS: The first aim of this study was to compare salivary mtDNA-cn between 49 depressed and/or anxious adolescents and 35 well-matched healthy controls. The second aim of this study was to identify neural correlates of mtDNA-cn derived from diffusion tensor imaging (DTI) and tractography, in the full sample of adolescents.RESULTS: There were no diagnosis-specific alterations in mtDNA-cn. However, there was a positive correlation between mtDNA-cn and levels of anxiety, but not depression, in the full sample of adolescents. A subnetwork of connections largely corresponding to the left fronto-occipital fasciculus had significantly lower fractional anisotropy (FA) values in adolescents with higher than median mtDNA-cn.LIMITATIONS: Undifferentiated analysis of free and intracellular mtDNA and use of DTI-based tractography represent this study's limitations.CONCLUSIONS: The results of this study help elucidate the relationships between clinical symptoms, molecular changes, and neurocircuitry alterations in adolescents with and without anxiety and depression, and they suggest that increased mtDNA-cn is associated both with increased anxiety symptoms and with decreased fronto-occipital structural connectivity in this population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Adolescent depression
- Anxiety
- Brain connectivity
- DTI
- MRI
- Mitochondrial DNA
- Adolescent depression
- Anxiety
- Brain connectivity
- DTI
- Mitochondrial DNA
- MRI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tymofiyeva, Olga
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Henje Blom, Eva
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Ho, Tiffany C.
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Connolly, Colm G ...
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Lindqvist, Danie ...
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Wolkowitz, Owen ...
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visa fler...
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Lin, Jue
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LeWinn, Kaja Z.
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Sacchet, Matthew ...
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Han, Laura K. M.
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Yuan, Justin P.
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Bhandari, Sarina ...
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Xu, Duan
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Yang, Tony T.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Journal of Affec ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet
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Lunds universitet