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Past and current ca...
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Hjortshøj, Cristel M SørensenCopenhagen University Hospital
(författare)
Past and current cause-specific mortality in Eisenmenger syndrome.
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-04-18
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Oxford University Press (OUP),2017
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-146411
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146411URI
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https://doi.org/10.1093/eurheartj/ehx201DOI
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https://lup.lub.lu.se/record/ab4431c6-f896-44c3-9f5d-c1c8f1ce1e10URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136165710URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Aims: Eisenmenger syndrome (ES) is associated with considerable morbidity and mortality. Therapeutic strategies have changed during the 2000s in conjunction with an emphasis on specialist follow-up. The aim of this study was to determine the cause-specific mortality in ES and evaluate any relevant changes between 1977 and 2015.Methods and results: This is a retrospective, descriptive multicentre study. A total of 1546 patients (mean age 38.7 ± 15.4 years; 36% male) from 13 countries were included. Cause-specific mortality was examined before and after July 2006, 'early' and 'late', respectively. Over a median follow-up of 6.1 years (interquartile range 2.1-21.5 years) 558 deaths were recorded; cause-specific mortality was identified in 411 (74%) cases. Leading causes of death were heart failure (34%), infection (26%), sudden cardiac death (10%), thromboembolism (8%), haemorrhage (7%), and peri-procedural (7%). Heart failure deaths increased in the 'late' relative to the 'early' era (P = 0.032), whereas death from thromboembolic events and death in relation to cardiac and non-cardiac procedures decreased (P = 0.014, P = 0.014, P = 0.004, respectively). There was an increase in longevity in the 'late' vs. 'early' era (median survival 52.3 vs. 35.2 years, P < 0.001).Conclusion: The study shows that despite changes in therapy, care, and follow-up of ES in tertiary care centres, all-cause mortality including cardiac remains high. Patients from the 'late' era, however, die later and from chronic rather than acute cardiac causes, primarily heart failure, whereas peri-procedural and deaths due to haemoptysis have become less common. Lifelong vigilance in tertiary centres and further research for ES are clearly needed.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kempny, AleksanderRoyal Brompton Hospital
(författare)
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Jensen, Annette SchophuusCopenhagen University Hospital
(författare)
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Sørensen, KeldAalborg University
(författare)
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Nagy, EditKarolinska Institutet,Karolinska Institute,Karolinska University Hospital
(författare)
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Dellborg, MikaelSahlgrenska Academy
(författare)
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Johansson, BengtNorrland University Hospital
(författare)
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Rudiene, VirginijaVilnius University
(författare)
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Hong, GuCapital University of Medical Sciences
(författare)
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Opotowsky, Alexander RBrigham and Women's Hospital / Harvard Medical School
(författare)
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Budts, WernerUniversity Hospitals Leuven
(författare)
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Mulder, Barbara JAcademic Medical Center of University of Amsterdam (AMC)
(författare)
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Tomkiewicz-Pajak, LidiaJagiellonian University
(författare)
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D'Alto, MicheleUniversity of Campania Luigi Vanvitelli
(författare)
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Prokšelj, KatjaUniversity Medical Centre Ljubljana
(författare)
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Diller, Gerhard-PaulRoyal Brompton Hospital
(författare)
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Dimopoulos, KonstantinosRoyal Brompton Hospital
(författare)
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Estensen, Mette-EliseNorwegian Radium Hospital
(författare)
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Holmstrøm, HenrikNorwegian Radium Hospital
(författare)
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Turanlahti, MailaHelsinki University Central Hospital
(författare)
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Thilén, UlfLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-uth
(författare)
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Gatzoulis, Michael ARoyal Brompton Hospital
(författare)
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Søndergaard, LarsCopenhagen University Hospital
(författare)
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Copenhagen University HospitalRoyal Brompton Hospital
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Heart Journal: Oxford University Press (OUP)38:26, s. 2060-20670195-668X1522-9645
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Hjortshøj, Crist ...
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Kempny, Aleksand ...
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Jensen, Annette ...
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Sørensen, Keld
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Nagy, Edit
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Dellborg, Mikael
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Johansson, Bengt
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Rudiene, Virgini ...
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Hong, Gu
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Opotowsky, Alexa ...
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Budts, Werner
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Mulder, Barbara ...
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Tomkiewicz-Pajak ...
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D'Alto, Michele
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Prokšelj, Katja
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Diller, Gerhard- ...
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Dimopoulos, Kons ...
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Estensen, Mette- ...
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Holmstrøm, Henri ...
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Turanlahti, Mail ...
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Thilén, Ulf
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Gatzoulis, Micha ...
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Søndergaard, Lar ...
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