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(WFRF:(Kaaks Rudolf)) srt2:(2015-2019) pers:(Weiderpass Elisabete) pers:(Quirós J. Ramón)
 

Search: (WFRF:(Kaaks Rudolf)) srt2:(2015-2019) pers:(Weiderpass Elisabete) pers:(Quirós J. Ramón) > (2017) > Exposure to bacteri...

  • Fedirko, VeronikaEmory University (author)

Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma : a nested case-control study

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-04-04
  • BioMed Central,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-146516
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146516URI
  • https://doi.org/10.1186/s12916-017-0830-8DOI
  • https://lup.lub.lu.se/record/4639ae85-9e10-4c8b-a422-c74160a88d7bURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135471984URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.METHODS: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. A total of 139 men and women diagnosed with hepatocellular carcinoma between 1992 and 2010 were matched to 139 control subjects. Multivariable rate ratios (RRs), including adjustment for potential confounders, hepatitis B/C positivity, and degree of liver dysfunction, were calculated with conditional logistic regression.RESULTS:  = 0.021). This finding did not vary substantially by time from enrollment to diagnosis, and did not change after adjustment for chronic infection with hepatitis B and C viruses.CONCLUSIONS: These novel findings, based on exposures up to several years prior to diagnosis, support a role for gut-derived bacterial products in hepatocellular carcinoma development. Further study into the role of gut barrier failure and exposure to bacterial products in liver diseases is warranted.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tran, Hao QuangGeorgia State University (author)
  • Gewirtz, Andrew TGeorgia State University (author)
  • Stepien, MagdalenaInternational Agency for Research on Cancer, World Health Organization (author)
  • Trichopoulou, AntoniaNational and Kapodistrian University of Athens (author)
  • Aleksandrova, KrasimiraGerman Institute of Human Nutrition (author)
  • Olsen, AnjaDanish Cancer Society (author)
  • Tjønneland, AnneDanish Cancer Society (author)
  • Overvad, KimAarhus University (author)
  • Carbonnel, FranckUniversity of Paris-Saclay (author)
  • Boutron-Ruault, Marie-ChristineUniversity of Paris-Saclay (author)
  • Severi, GianlucaUniversity of Paris-Saclay (author)
  • Kühn, TilmanGerman Cancer Research Centre(Swepub:lu)extLU-26 (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Boeing, HeinerGerman Institute of Human Nutrition,University of Malaya (author)
  • Bamia, ChristinaNational and Kapodistrian University of Athens (author)
  • Lagiou, PagonaNational and Kapodistrian University of Athens (author)
  • Grioni, SaraIstituto Nazionale dei Tumori (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (author)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (author)
  • Naccarati, AlessioHuman Genetics Foundation (HuGeF) (author)
  • Peeters, Petra HUniversity Medical Center Utrecht (author)
  • Bueno-de-Mesquita, H B (author)
  • Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute (author)
  • Castaño, José María HuertaCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Barricarte, AurelioCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Sánchez, María-JoséCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Dorronsoro, MirenCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Quirós, J RamónPublic Health Directorate (author)
  • Agudo, AntonioCatalan Institute of Oncology (author)
  • Sjöberg, KlasLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-ksj (author)
  • Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-boh (author)
  • Hemmingsson, OskarDepartment of Surgical and Perioperative Sciences, Kirurgcentrum, Norrlands Universitetssjukhus, Umeå, Sweden,Norrland University Hospital(Swepub:umu)osrhen96 (author)
  • Werner, MårtenDepartment of Medicine Sections for Hepatology and Gastroenterology, Umeå University Hospital, SE-90185 Umeå, Sweden,Norrland University Hospital(Swepub:umu)manwer04 (author)
  • Bradbury, Kathryn EUniversity of Oxford (author)
  • Khaw, Kay-TeeUniversity of Cambridge (author)
  • Wareham, NickUniversity of Cambridge (author)
  • Tsilidis, Konstantinos KUniversity of Ioannina (author)
  • Aune, DagfinnImperial College London (author)
  • Scalbert, AugustinInternational Agency for Research on Cancer, World Health Organization (author)
  • Romieu, IsabelleInternational Agency for Research on Cancer, World Health Organization (author)
  • Riboli, ElioImperial College London (author)
  • Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization (author)
  • Emory UniversityGeorgia State University (creator_code:org_t)

Related titles

  • In:BMC Medicine: BioMed Central72:151741-7015

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