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  • Neely, G GregoryAustrian Academy of Science (author)

A Genome-wide Drosophila Screen for Heat Nociception Identifies alpha 2 delta 3 as an Evolutionarily Conserved Pain Gene

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • Elsevier Science B.V., Amsterdam.2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-146706
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146706URI
  • https://doi.org/10.1016/j.cell.2010.09.047DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-62750URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an innate behavior and identify hundreds of genes implicated in heat nociception, including the alpha 2 delta family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (alpha 2 delta 3) also exhibit impaired behavioral heat pain sensitivity. In addition, in humans, alpha 2 delta 3 SNP variants associate with reduced sensitivity to acute noxious heat and chronic back pain. Functional imaging in alpha 2 delta 3 mutant mice revealed impaired transmission of thermal pain-evoked signals from the thalamus to higher-order pain centers. Intriguingly, in alpha 2 delta 3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hess, AndreasUniversity of Erlangen Nurnberg (author)
  • Costigan, MichaelHarvard University (author)
  • Keene, Alex CNYU (author)
  • Goulas, SpyrosAustrian Academy of Science (author)
  • Langeslag, MichielInnsbruck Medical University (author)
  • Griffin, Robert SMassachusetts General Hospital,Strand Life Science Pvt Ltd (author)
  • Belfer, InnaUniversity of Pittsburgh (author)
  • Dai, FengUniversity of Pittsburgh (author)
  • Smith, Shad BUniversity N Carolina (author)
  • Diatchenko, LudaUniversity N Carolina (author)
  • Gupta, VaijayantiStrand Life Science Pvt Ltd (author)
  • Xia, Cui-PingAustrian Academy Science (author)
  • Amann, SabinaAustrian Academy of Science (author)
  • Kreitz, SilkeUniversity of Erlangen Nurnberg (author)
  • Heindl-Erdmann, CorneliaUniversity of Erlangen Nurnberg (author)
  • Wolz, SusanneUniversity of Erlangen Nurnberg (author)
  • Ly, Cindy VStrand Life Science Pvt Ltd (author)
  • Sarangi, RinkuStrand Life Science Pvt Ltd (author)
  • Dan, DebasisStrand Life Science Pvt Ltd (author)
  • Novatchkova, MariaAustrian Academy of Science (author)
  • Rosenzweig, MarkBrandeis University (author)
  • Gibson, Dustin GUniversity N Carolina (author)
  • Truong, DarwinAustrian Academy of Science (author)
  • Schramek, DanielAustrian Academy of Science (author)
  • Zoranovic, TamaraAustrian Academy of Science (author)
  • Cronin, Shane J FAustrian Academy of Science (author)
  • Angjeli, BelindaAustrian Academy of Science (author)
  • Brune, KayUniversity of Erlangen Nurnberg (author)
  • Dietzl, GeorgStanford University (author)
  • Maixner, WilliamUniversity N Carolina (author)
  • Meixner, ArabellaAustrian Academy of Science (author)
  • Thomas, WinstonDeltagen Inc (author)
  • Pospisilik, J AndrewMax Planck Institute (author)
  • Alenius, MattiasLinköpings universitet,Hälsouniversitetet,Utvecklingsbiologi(Swepub:liu)matal21 (author)
  • Kress, MichaelaInnsbruck Medical University (author)
  • Subramaniam, SaiStrand Life Science Pvt Ltd (author)
  • Garrity, Paul ABrandeis University (author)
  • Bellen, Hugo JBaylor College of Medicine (author)
  • Woolf, Clifford JHarvard University (author)
  • Penninger, Josef MAustrian Academy of Science (author)
  • Austrian Academy of ScienceUniversity of Erlangen Nurnberg (creator_code:org_t)

Related titles

  • In:Cell: Elsevier Science B.V., Amsterdam.143:4, s. 628-6380092-86741097-4172

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