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Impaired functional...
Impaired functional vitamin B6 status is associated with increased risk of lung cancer
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- Theofylaktopoulou, Despoina (author)
- University of Bergen
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- Midttun, Oivind (author)
- Bevital AS
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- Ueland, Per M. (author)
- University of Bergen,Haukeland University Hospital
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- Meyer, Klaus (author)
- Bevital AS
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- Fanidi, Anouar (author)
- University of Cambridge,International Agency for Research on Cancer, World Health Organization
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- Zheng, Wei (author)
- Vanderbilt University
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- Shu, Xiao-Ou (author)
- Vanderbilt University
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- Xiang, Yong-Bing (author)
- Vanderbilt University,Renji Hospital
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- Prentice, Ross (author)
- Fred Hutchinson Cancer Research Center
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- Pettinger, Mary (author)
- Fred Hutchinson Cancer Research Center
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- Thomson, Cynthia A. (author)
- University of Arizona
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- Giles, Graham G. (author)
- Cancer Council Victoria,University of Melbourne
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- Hodge, Allison (author)
- Cancer Council Victoria,University of Melbourne
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- Cai, Qiuyin (author)
- Vanderbilt University
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- Blot, William J. (author)
- Vanderbilt University
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- Wu, Jie (author)
- Vanderbilt University
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- Johansson, Mikael (author)
- Umeå University,Umeå universitet,Onkologi,Veterans Health Administration,Brigham and Women's Hospital / Harvard Medical School
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- Hultdin, Johan (author)
- Umeå University,Umeå universitet,Klinisk kemi
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- Grankvist, Kjell (author)
- Umeå University,Umeå universitet,Klinisk kemi
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- Stevens, Victoria L. (author)
- American Cancer Society
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- McCullough, Marjorie M. (author)
- American Cancer Society,University of Pittsburgh Cancer Institute
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- Weinstein, Stephanie J. (author)
- National Cancer Institute, USA
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- Albanes, Demetrius (author)
- National Cancer Institute, USA
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- Ziegler, Regina (author)
- National Cancer Institute, USA
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- Freedman, Neal D. (author)
- National Cancer Institute, USA
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- Langhammer, Arnulf (author)
- Norwegian University of Science and Technology
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- Hveem, Kristian (author)
- Norwegian University of Science and Technology
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Naess, Marit (author)
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- Sesso, Howard D. (author)
- Brigham and Women's Hospital / Harvard Medical School,Harvard T.H. Chan School of Public Health
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Gaziano, J. Michael (author)
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- Buring, Julie E. (author)
- Brigham and Women's Hospital / Harvard Medical School,Harvard T.H. Chan School of Public Health
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- Lee, I-Min (author)
- Brigham and Women's Hospital / Harvard Medical School,Harvard T.H. Chan School of Public Health
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- Severi, Gianluca (author)
- Human Genetics Foundation (HuGeF),University of Paris-Saclay
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- Zhang, Xuehong (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Stampfer, Meir J. (author)
- Harvard T.H. Chan School of Public Health,Brigham and Women's Hospital / Harvard Medical School
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- Han, Jiali (author)
- Harvard T.H. Chan School of Public Health
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- Smith-Warner, Stephanie A. (author)
- Harvard T.H. Chan School of Public Health
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- Zeleniuch-Jacquotte, Anne (author)
- New York University
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- Le Marchand, Loic (author)
- University of Hawaii Cancer Center
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- Yuan, Jian-Min (author)
- University of Pittsburgh Cancer Institute,University of Pittsburgh
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- Wang, Renwei (author)
- University of Pittsburgh Cancer Institute
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Butler, Lesley M. (author)
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- Koh, Woon-Puay (author)
- National University of Singapore
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- Gao, Yu-Tang (author)
- Shanghai Jiao Tong University
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- Rothman, Nathaniel (author)
- National Cancer Institute, USA
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Visvanathan, Kala (author)
- Johns Hopkins Bloomberg School of Public Health
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- Jones, Miranda R. (author)
- Johns Hopkins Bloomberg School of Public Health
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- Relton, Caroline (author)
- University of Newcastle upon Tyne,University of Bristol
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- Brennan, Paul (author)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, World Health Organization
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- Ulvik, Arve (author)
- Bevital AS
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- Næss, Marit (author)
- Norwegian University of Science and Technology
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(creator_code:org_t)
- 2018-01-04
- 2018
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 142:12, s. 2425-2434
- Related links:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Circulating vitamin B6 levels have been found to be inversely associated with lung cancer. Most studies have focused on the B6 form pyridoxal 5'-phosphate (PLP), a direct biomarker influenced by inflammation and other factors. Using a functional B6 marker allows further investigation of the potential role of vitamin B6 status in the pathogenesis of lung cancer. We prospectively evaluated the association of the functional marker of vitamin B6 status, the 3-hydroxykynurenine:xanthurenic acid (HK:XA) ratio, with risk of lung cancer in a nested case-control study consisting of 5,364 matched case-control pairs from the Lung Cancer Cohort Consortium (LC3). We used conditional logistic regression to evaluate the association between HK:XA and lung cancer, and random effect models to combine results from different cohorts and regions. High levels of HK:XA, indicating impaired functional B6 status, were associated with an increased risk of lung cancer, the odds ratio comparing the fourth and the first quartiles (OR4th vs. 1st) was 1.25 (95% confidence interval, 1.10-1.41). Stratified analyses indicated that this association was primarily driven by cases diagnosed with squamous cell carcinoma. Notably, the risk associated with HK:XA was approximately 50% higher in groups with a high relative frequency of squamous cell carcinoma, i.e., men, former and current smokers. This risk of squamous cell carcinoma was present in both men and women regardless of smoking status.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- pyridoxal 5 '-phosphate
- functional vitamin B6 marker
- 3-hydroxykynurenine:xanthurenic acid
- Lung ncer Cohort Consortium
- 3-hydroxykynurenine:xanthurenic acid
- functional vitamin B6 marker
- Lung Cancer Cohort Consortium
- pyridoxal 5′-phosphate
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Theofylaktopoulo ...
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Midttun, Oivind
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Ueland, Per M.
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Meyer, Klaus
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Fanidi, Anouar
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Zheng, Wei
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show more...
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Shu, Xiao-Ou
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Xiang, Yong-Bing
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Prentice, Ross
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Pettinger, Mary
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Thomson, Cynthia ...
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Giles, Graham G.
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Hodge, Allison
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Cai, Qiuyin
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Blot, William J.
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Wu, Jie
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Johansson, Mikae ...
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Hultdin, Johan
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Grankvist, Kjell
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Stevens, Victori ...
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McCullough, Marj ...
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Weinstein, Steph ...
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Albanes, Demetri ...
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Ziegler, Regina
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Freedman, Neal D ...
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Langhammer, Arnu ...
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Hveem, Kristian
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Naess, Marit
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Sesso, Howard D.
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Gaziano, J. Mich ...
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Buring, Julie E.
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Lee, I-Min
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Severi, Gianluca
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Zhang, Xuehong
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Stampfer, Meir J ...
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Han, Jiali
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Smith-Warner, St ...
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Zeleniuch-Jacquo ...
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Le Marchand, Loi ...
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Yuan, Jian-Min
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Wang, Renwei
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Butler, Lesley M ...
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Koh, Woon-Puay
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Gao, Yu-Tang
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Rothman, Nathani ...
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Ericson, Ulrika
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Sonestedt, Emily
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Visvanathan, Kal ...
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Jones, Miranda R ...
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Relton, Caroline
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Brennan, Paul
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Johansson, Matti ...
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Ulvik, Arve
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Næss, Marit
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Lund University