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Interaction of Diet...
Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study
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- Meidtner, Karina (författare)
- German Institute of Human Nutrition,German Center for Diabetes Research
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- Podmore, Clara (författare)
- University of Cambridge
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- Kroger, Janine (författare)
- German Institute of Human Nutrition
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- van der Schouw, Yvonne T. (författare)
- University Medical Center Utrecht
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- Bendinelli, Benedetta (författare)
- Cancer Research and Prevention Institute (ISPO),German Center for Diabetes Research,German Institute of Human Nutrition
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- Agnoli, Claudia (författare)
- Istituto Nazionale dei Tumori
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- Arriola, Larraitz (författare)
- Biodonostia Health Research Institute,Public Health Division of Gipuzkoa,CIBER Epidemiology and Public Health (CIBERESP)
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- Barricarte, Aurelio (författare)
- Navarre Public Health Institute (ISPN),CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Cross, Amanda J. (författare)
- Imperial College London,International Agency for Research on Cancer, World Health Organization
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- Dow, Courtney (författare)
- Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Institut Gustave Roussy
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- Ekblom, Kim (författare)
- Umeå University,Umeå universitet,Klinisk kemi
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- Fagherazzi, Guy (författare)
- Institut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)
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- Franks, Paul W. (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Huerta, Jose Maria (författare)
- Biodonostia Health Research Institute,Murcia Regional Health Council
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- Jakszyn, Paula (författare)
- Ramon Llull University,Catalan Institute of Oncology
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Jenab, Mazda (författare)
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- Katzke, Verena A. (författare)
- German Cancer Research Centre
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- Key, Timothy J. (författare)
- University of Oxford
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- Khaw, Kay Tee (författare)
- University of Cambridge
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- Kuhn, Tilman (författare)
- German Cancer Research Centre
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- Kyro, Cecilie (författare)
- Danish Cancer Society
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- Mancini, Francesca Romana (författare)
- Institut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Overvad, Kim (författare)
- Aarhus University,Aalborg University
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Quiros, J. Ramon (författare)
- Public Health Directorate
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- Rodriguez-Barranco, Miguel (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin,Human Genetics Foundation (HuGeF)
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- Sluijs, Ivonne (författare)
- University Medical Center Utrecht
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- Stepien, Magdalena (författare)
- International Agency for Research on Cancer, World Health Organization
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Tumino, Rosario (författare)
- L’ Associazione Iblea per la Ricerca Epidemiologica (A.I.R.E.),Civic and M.P Arezzo Hospital
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- Forouhi, Nita G. (författare)
- University of Cambridge
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- Sharp, Stephen J. (författare)
- University of Cambridge
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- Langenberg, Claudia (författare)
- University of Cambridge
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Schulze, Matthias B. (författare)
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- Riboli, Elio (författare)
- Imperial College London
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- Wareham, Nicholas J. (författare)
- University of Cambridge
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(creator_code:org_t)
- 2017-11-22
- 2018
- Engelska.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 41:2, s. 277-285
- Relaterad länk:
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https://care.diabete...
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visa fler...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes.RESEARCH DESIGN AND METHODS: The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression.RESULTS: Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (−0.019 [−0.043; 0.006]) or transferrin saturation (0.016 [−0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03).CONCLUSIONS: We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Meidtner, Karina
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Podmore, Clara
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Kroger, Janine
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van der Schouw, ...
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Bendinelli, Bene ...
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Agnoli, Claudia
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visa fler...
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Arriola, Larrait ...
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Barricarte, Aure ...
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Boeing, Heiner
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Cross, Amanda J.
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Dow, Courtney
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Ekblom, Kim
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Fagherazzi, Guy
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Franks, Paul W.
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Gunter, Marc J.
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Huerta, Jose Mar ...
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Jakszyn, Paula
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Jenab, Mazda
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Katzke, Verena A ...
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Key, Timothy J.
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Khaw, Kay Tee
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Kuhn, Tilman
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Kyro, Cecilie
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Mancini, Frances ...
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Melander, Olle
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Nilsson, Peter M ...
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Overvad, Kim
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Palli, Domenico
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Panico, Salvator ...
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Quiros, J. Ramon
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Rodriguez-Barran ...
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Sacerdote, Carlo ...
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Sluijs, Ivonne
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Stepien, Magdale ...
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Tjonneland, Anne
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Tumino, Rosario
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Forouhi, Nita G.
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Sharp, Stephen J ...
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Langenberg, Clau ...
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Schulze, Matthia ...
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Riboli, Elio
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Wareham, Nichola ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Umeå universitet
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Lunds universitet