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The Nordic SentiMag...
The Nordic SentiMag trial : a comparison of super paramagnetic iron oxide (SPIO) nanoparticles versus Tc(99) and patent blue in the detection of sentinel node (SN) in patients with breast cancer and a meta-analysis of earlier studies.
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- Karakatsanis, Andreas (författare)
- Uppsala universitet,Endokrinkirurgi,University of Uppsala Hospital, Sweden
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- Christiansen, Peer Michael (författare)
- Aarhus Univ Hosp, Randers Reg Hosp, Dept Surg, Breast Unit, DK-8000 Aarhus, Denmark.,Aarhus University Hospital, Denmark
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- Fischer, Lone (författare)
- Aarhus Univ Hosp, Randers Reg Hosp, Dept Surg, Breast Unit, DK-8000 Aarhus, Denmark.,Aarhus University Hospital, Denmark
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- Hedin, Christina (författare)
- Linkoping Univ Hosp, Dept Surg, Breast Unit, S-58185 Linkoping, Sweden.,Region Östergötland, Kirurgiska kliniken US
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- Pistioli, Lida (författare)
- Linkoping Univ Hosp, Dept Surg, Breast Unit, S-58185 Linkoping, Sweden.,Region Östergötland, Kirurgiska kliniken US
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- Sund, Malin (författare)
- Umeå universitet,Kirurgi,Dept Surg & Perioperat Sci, Umea, Sweden.,Department Surg and Perioperat Science, Sweden
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- Rasmussen, Nils Ryegaard (författare)
- SVS, Dept Surg, Breast Unit, Esbjerg, Denmark.
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- Jørnsgård, Hjørdis (författare)
- SVS, Dept Surg, Breast Unit, Esbjerg, Denmark.
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- Tegnelius, Daniel (författare)
- Univ Orebro, Dept Surg, Breast Unit, SE-70182 Orebro, Sweden.,University of Örebro, Sweden
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- Eriksson, Staffan (författare)
- Vastmanland Cty Hosp, Dept Surg, Vasteras, Sweden.,Vastmanland County Hospital, Sweden
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- Daskalakis, Kosmas (författare)
- Uppsala universitet,Endokrinkirurgi,University of Uppsala Hospital, Sweden
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- Wärnberg, Fredrik (författare)
- Uppsala universitet,Endokrinkirurgi,University of Uppsala Hospital, Sweden
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- Markopoulos, Christos J. (författare)
- Univ Athens, Sch Med, Athens 11528, Greece.,University of Athens, Greece
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- Bergkvist, Leif (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Vastmanland Cty Hosp, Dept Surg, Vasteras, Sweden.,Uppsala University, Sweden; Vastmanland County Hospital, Sweden
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(creator_code:org_t)
- 2016-04-27
- 2016
- Engelska.
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Ingår i: Breast Cancer Research and Treatment. - New York : Springer-Verlag New York. - 0167-6806 .- 1573-7217. ; 157:2, s. 281-294
- Relaterad länk:
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https://link.springe...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The aim of the study is to compare the efficacy of SPIO as a tracer in sentinel node biopsy (SNB) in breast cancer with Tc and patent blue in a multicentre prospective study and perform a meta-analysis of all published studies. It also aims to follow skin discoloration after SPIO injection and describe when and how it resolves. Totally 206 patients with early breast cancer were recruited. Tc and patent blue were administered in standard fashion. Patients were injected with SPIO (Sienna+) preoperatively. SNB was performed and detection rates were recorded for both methods. Skin discoloration was followed and documented postoperatively. Data extraction and subsequent meta-analysis of all previous studies were also performed. SN detection rates were similar between standard technique succeeded and SPIO both per patient (97.1 vs. 97.6 %, p = 0.76) as well as per node (91.3 vs. 93.3 %, p = 0.34), something which was not affected by the presence of malignancy. Concordance rates were also consistently high (98.0 % per patient and 95.9 % per node). Discoloring was present in 35.5 % of patients postoperatively, almost exclusively in breast conservation. It fades slowly and is still detectable in 8.6 % of patients after 15 months. Meta-analysis depicted similar detection rates (p = 0.71) and concordance rates (p = 0.82) per patient. However, it seems that SPIO is characterized by higher nodal retrieval (p < 0.001). SPIO is an effective method for the detection of SN in patients with breast cancer. It is comparable to the standard technique and seems to simplify logistics. Potential skin discoloration is something of consideration in patients planned for breast conservation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast cancer
- Sentinel node
- Super paramagnetic iron oxide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Karakatsanis, An ...
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Christiansen, Pe ...
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Fischer, Lone
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Hedin, Christina
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Pistioli, Lida
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Sund, Malin
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Rasmussen, Nils ...
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Jørnsgård, Hjørd ...
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Tegnelius, Danie ...
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Eriksson, Staffa ...
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Daskalakis, Kosm ...
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Wärnberg, Fredri ...
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Markopoulos, Chr ...
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Bergkvist, Leif
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Breast Cancer Re ...
- Av lärosätet
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Umeå universitet
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Uppsala universitet
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Linköpings universitet