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  • Scott, R. A. (author)

The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors : the EPIC-InterAct study

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2012-09-28
  • Springer,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-148531
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-148531URI
  • https://doi.org/10.1007/s00125-012-2715-xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aims/hypothesis: Although a family history of type 2 diabetes is a strong risk factor for the disease, the factors mediating this excess risk are poorly understood. In the InterAct case-cohort study, we investigated the association between a family history of diabetes among different family members and the incidence of type 2 diabetes, as well as the extent to which genetic, anthropometric and lifestyle risk factors mediated this association.Methods: A total of 13,869 individuals (including 6,168 incident cases of type 2 diabetes) had family history data available, and 6,887 individuals had complete data on all mediators. Country-specific Prentice-weighted Cox models were fitted within country, and HRs were combined using random effects meta-analysis. Lifestyle and anthropometric measurements were performed at baseline, and a genetic risk score comprising 35 polymorphisms associated with type 2 diabetes was created.Results: A family history of type 2 diabetes was associated with a higher incidence of the condition (HR 2.72, 95% CI 2.48, 2.99). Adjustment for established risk factors including BMI and waist circumference only modestly attenuated this association (HR 2.44, 95% CI 2.03, 2.95); the genetic score alone explained only 2% of the family history-associated risk of type 2 diabetes. The greatest risk of type 2 diabetes was observed in those with a biparental history of type 2 diabetes (HR 5.14, 95% CI 3.74, 7.07) and those whose parents had been diagnosed with diabetes at a younger age (<50 years; HR 4.69, 95% CI 3.35, 6.58), an effect largely confined to a maternal family history.Conclusions/interpretation: Prominent lifestyle, anthropometric and genetic risk factors explained only a marginal proportion of the excess risk associated with family history, highlighting the fact that family history remains a strong, independent and easily assessed risk factor for type 2 diabetes. Discovering factors that will explain the association of family history with type 2 diabetes risk will provide important insight into the aetiology of type 2 diabetes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Langenberg, C. (author)
  • Sharp, S. J. (author)
  • Franks, Paul W.Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Lund University, Malmö, Sweden(Swepub:umu)pafr0003 (author)
  • Rolandsson, OlovUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)olro0005 (author)
  • Drogan, D. (author)
  • van der Schouw, Y. T. (author)
  • Ekelund, U. (author)
  • Kerrison, N. D. (author)
  • Ardanaz, E. (author)
  • Arriola, L. (author)
  • Balkau, B. (author)
  • Barricarte, A. (author)
  • Barroso, I. (author)
  • Bendinelli, B. (author)
  • Beulens, J. W. J. (author)
  • Boeing, H. (author)
  • de Lauzon-Guillain, B. (author)
  • Deloukas, P. (author)
  • Fagherazzi, G. (author)
  • Gonzalez, C. (author)
  • Griffin, S. J. (author)
  • Groop, L. C. (author)
  • Halkjaer, J. (author)
  • Huerta, J. M. (author)
  • Kaaks, R. (author)
  • Khaw, K. T. (author)
  • Krogh, V. (author)
  • Nilsson, P. M. (author)
  • Norat, T. (author)
  • Overvad, K. (author)
  • Panico, S. (author)
  • Rodriguez-Suarez, L. (author)
  • Romaguera, D. (author)
  • Romieu, I. (author)
  • Sacerdote, C. (author)
  • Sánchez, M. J. (author)
  • Spijkerman, A. M. W. (author)
  • Teucher, B. (author)
  • Tjonneland, A. (author)
  • Tumino, R. (author)
  • van der A, D. L. (author)
  • Wark, P. A. (author)
  • McCarthy, M. I. (author)
  • Riboli, E. (author)
  • Wareham, N. J. (author)
  • Umeå universitetInstitutionen för folkhälsa och klinisk medicin (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer56:1, s. 60-690012-186X1432-0428

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