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Search: (WFRF:(Houlston Richard)) pers:(Barnholtz Sloan Jill S.) > Influence of obesit...

  • Disney-Hogg, Linden (author)

Influence of obesity-related risk factors in the aetiology of glioma

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-03-13
  • Nature Publishing Group,2018
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-148648
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-148648URI
  • https://doi.org/10.1038/s41416-018-0009-xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. METHODS: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. RESULTS: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. CONCLUSIONS: This study provides no evidence to implicate obesity-related factors as causes of glioma.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sud, Amit (author)
  • Law, Philip J. (author)
  • Cornish, Alex J. (author)
  • Kinnersley, Ben (author)
  • Ostrom, Quinn T. (author)
  • Labreche, Karim (author)
  • Eckel-Passow, Jeanette E. (author)
  • Armstrong, Georgina N. (author)
  • Claus, Elizabeth B. (author)
  • Il'yasova, Dora (author)
  • Schildkraut, Joellen (author)
  • Barnholtz-Sloan, Jill S. (author)
  • Olson, Sara H. (author)
  • Bernstein, Jonine L. (author)
  • Lai, Rose K. (author)
  • Swerdlow, Anthony J. (author)
  • Simon, Matthias (author)
  • Hoffmann, Per (author)
  • Nöthen, Markus M. (author)
  • Jöckel, Karl-Heinz (author)
  • Chanock, Stephen (author)
  • Rajaraman, Preetha (author)
  • Johansen, Christoffer (author)
  • Jenkins, Robert B. (author)
  • Melin, Beatrice S.Umeå universitet,Onkologi(Swepub:umu)bema0010 (author)
  • Wrensch, Margaret R. (author)
  • Sanson, Marc (author)
  • Bondy, Melissa L. (author)
  • Houlston, Richard S. (author)
  • Umeå universitetOnkologi (creator_code:org_t)

Related titles

  • In:British Journal of Cancer: Nature Publishing Group118:7, s. 1020-10270007-09201532-1827

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