A generic health-related quality of life instrument for assessing pelvic organ prolapse surgery: correlation with condition-specific outcome measures

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Altman, DanielKarolinska Institutet,Uppsala universitet,Reproduktiv hälsa,Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden;Stockholm Urogynecol Clin, Stockholm, Sweden (författare)

A generic health-related quality of life instrument for assessing pelvic organ prolapse surgery : correlation with condition-specific outcome measures

Artikel/kapitelEngelska2018

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2018-03-06
Springer,2018
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-150350
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150350URI
https://doi.org/10.1007/s00192-018-3587-5DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361503URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:138726264URI

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Språk:engelska
Sammanfattning på:engelska

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Introduction and hypothesis: The aim of this study was to investigate the use of a generic and globally accessible instrument for assessing health-related quality of life (HR-QoL) in pelvic organ prolapse (POP) surgery.Methods: In a prospective multicenter setting, 207 women underwent surgery for apical prolapse [stage ae2, Pelvic Organ Prolapse Quantificcation (POP-Q) system] with or without anterior wall defect. Demographic and surgical characteristics were collected before surgery. Results of the 15-dimensional (15D) instrument and condition-specific pelvic floor symptoms as assessed using the Pelvic Floor Distress Inventory questionnaire (PFDI-20), including its subscales Pelvic Organ Prolapse Distress Inventory-6 (POPDI-6), Colorectal-Anal Distress Inventory-8 (CRADI-8), and Urinary Distress Inventory-6 (UDI-6), were assessed preoperatively and 2 months and 1 year after surgery.Results: HR-QoL as estimated by 15D was improved 1 year after surgery (p < 0.001). Prolapse-related 15D profile-index measures (excretion, discomfort, sexual activity, distress, and mobility) were significantly improved after surgery (p < 0.05-0.001). Significant inverse associations were detected between increased 15D scores and a decrease in PFDI-20 and subscale scores (p < 0.001), indicating improvements on both instruments.Conclusions: Generic HR-QoL as estimated by 15D improved significantly after apical POP surgery and correlated with improvements of condition-specific outcome measures. These results suggest that a comprehensive evaluation of global HR-QoL is valid in assessing pelvic reconstructive surgery and may provide novel and important insights into previously understudied areas, such as cost-utility and cost-effectiveness analysis after urogynecological surgery.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
15D
Pelvic floor condition-specific outcome measures
Urogynecological surgery
Quality of life

Biuppslag (personer, institutioner, konferenser, titlar ...)

Geale, KirkUmeå universitet,Dermatologi och venereologi,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden(Swepub:umu)kige0003 (författare)
Falconer, ChristianKarolinska Institutet (författare)
Morcos, EdwardKarolinska Institutet (författare)
Uppsala universitetReproduktiv hälsa (creator_code:org_t)

Sammanhörande titlar

Ingår i:International Urogynecology Journal: Springer29:8, s. 1093-10990937-34621433-3023

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Av författaren/redakt...: Altman, Daniel; Geale, Kirk; Falconer, Christ ...; Morcos, Edward

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

Artiklar i publikationen: International Ur ...

Av lärosätet: Umeå universitet; Uppsala universitet; Karolinska Institutet

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