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Tumor-associated au...
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Kaaks, RudolfGerman Cancer Research Centre
(författare)
Tumor-associated autoantibodies as early detection markers for ovarian cancer? : A prospective evaluation
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-03-08
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Wiley-Blackwell,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-150665
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150665URI
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https://doi.org/10.1002/ijc.31335DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138561242URI
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https://lup.lub.lu.se/record/1a14e39c-38f1-4587-a4fa-bbecdb8ef2d1URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Immuno-proteomic screening has identified several tumor-associated autoantibodies (AAb) that may have diagnostic capacity for invasive epithelial ovarian cancer, with AAbs to P53 proteins and cancer-testis antigens (CTAGs) as prominent examples. However, the early detection potential of these AAbs has been insufficiently explored in prospective studies. We performed ELISA measurements of AAbs to CTAG1A, CTAG2, P53 and NUDT11 proteins, for 194 patients with ovarian cancer and 705 matched controls from the European EPIC cohort, using serum samples collected up to 36 months prior to diagnosis under usual care. CA125 was measured using electrochemo-luminiscence. Diagnostic discrimination statistics were calculated by strata of lead-time between blood collection and diagnosis. With lead times 6 months, ovarian cancer detection sensitivity at 0.98 specificity (SE98) varied from 0.19 [95% CI 0.08-0.40] for CTAG1A, CTAG2 and NUDT1 to 0.23 [0.10-0.44] for P53 (0.33 [0.11-0.68] for high-grade serous tumors). However, at longer lead-times, the ability of these AAb markers to distinguish future ovarian cancer cases from controls declined rapidly; at lead times >1 year, SE98 estimates were close to zero (all invasive cases, range: 0.01-0.11). Compared to CA125 alone, combined logistic regression scores of AAbs and CA125 did not improve detection sensitivity at equal level of specificity. The added value of these selected AAbs as markers for ovarian cancer beyond CA125 for early detection is therefore limited. What's new? Could autoantibodies against tumor antigens provide an early warning system for ovarian cancer? These authors tested how well certain antibodies detected ovarian cancer. They selected four candidate antibodies, to p53, CTAG1A, CTAG2 and NUDT11 proteins, which appear in elevated levels in cancer patients. None of them performed well as a herald of burgeoning cancer. They did not perform any better than the best currently available biomarker, CA125, and as lead times increased past 6 months prediagnosis, the effectiveness diminished. Surprisingly, elevated antibodies appeared in quite a few of the control samples, suggesting they might not be as cancer-specific as expected.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fortner, Renée TurzanskiGerman Cancer Research Centre
(författare)
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Hüsing, AnikaGerman Cancer Research Centre
(författare)
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Barrdahl, MyrtoGerman Cancer Research Centre
(författare)
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Hopper, MarikaArizona State University
(författare)
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Johnson, TheronGerman Cancer Research Centre
(författare)
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Tjønneland, AnneDanish Cancer Society
(författare)
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Hansen, LouiseDanish Cancer Society
(författare)
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Overvad, KimAarhus University
(författare)
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Fournier, AgnèsUniversity of Paris-Saclay
(författare)
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Boutron-Ruault, Marie-ChristineUniversity of Paris-Saclay
(författare)
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Kvaskoff, MarinaUniversity of Paris-Saclay
(författare)
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Dossus, LaureInternational Agency for Research on Cancer, World Health Organization
(författare)
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Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization
(författare)
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Boeing, HeinerGerman Institute of Human Nutrition
(författare)
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Trichopoulou, AntoniaNational and Kapodistrian University of Athens
(författare)
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Benetou, VassilikiNational and Kapodistrian University of Athens
(författare)
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La Vecchia, CarloUniversity of Milan
(författare)
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Sieri, SabinaIstituto Nazionale dei Tumori,Arizona State University
(författare)
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Mattiello, Amalia
(författare)
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Palli, Domenico
(författare)
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Tumino, Rosario
(författare)
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Matullo, GiuseppeCitta' della Salute e della Scienza Hospital-University of Turin
(författare)
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Onland-Moret, N. CharlotteUniversity Medical Center Utrecht
(författare)
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Gram, Inger T.UiT The Arctic University of Norway, Tromsø
(författare)
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Weiderpass, ElisabeteKarolinska Institutet,Folkhälsan Research Center
(författare)
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Sánchez, Maria-Jose
(författare)
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Navarro Sanchez, CarmenMurcia Regional Health Council
(författare)
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Duell, Eric J.Catalan Institute of Oncology
(författare)
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Ardanaz, EvaSpanish Center for Biomedical Research Network in Oncology (CIBERONC)
(författare)
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Larranaga, Nerea
(författare)
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Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001
(författare)
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Idahl, Annika,1965-Umeå University,Umeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002
(författare)
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Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pat-kji
(författare)
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Nodin, BjörnLund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Skåne University Hospital(Swepub:lu)immu-bnn
(författare)
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Travis, Ruth C.
(författare)
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Riboli, ElioImperial College London
(författare)
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Merritt, Melissa
(författare)
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Aune, DagfinnImperial College London
(författare)
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Terry, Kathryn
(författare)
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Cramer, Daniel W.
(författare)
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Anderson, Karen S.
(författare)
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German Cancer Research CentreArizona State University
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Cancer: Wiley-Blackwell143:3, s. 515-5260020-71361097-0215
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Kaaks, Rudolf
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Fortner, Renée T ...
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Hüsing, Anika
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Barrdahl, Myrto
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Hopper, Marika
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Johnson, Theron
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visa fler...
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Tjønneland, Anne
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Hansen, Louise
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Overvad, Kim
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Fournier, Agnès
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Boutron-Ruault, ...
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Kvaskoff, Marina
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Dossus, Laure
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Johansson, Matti ...
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Boeing, Heiner
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Trichopoulou, An ...
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Benetou, Vassili ...
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La Vecchia, Carl ...
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Sieri, Sabina
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Mattiello, Amali ...
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Palli, Domenico
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Tumino, Rosario
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Matullo, Giusepp ...
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Onland-Moret, N. ...
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Gram, Inger T.
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Weiderpass, Elis ...
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Sánchez, Maria-J ...
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Navarro Sanchez, ...
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Duell, Eric J.
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Ardanaz, Eva
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Larranaga, Nerea
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Lundin, Eva
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Idahl, Annika, 1 ...
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Jirström, Karin
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Nodin, Björn
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Travis, Ruth C.
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Riboli, Elio
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Merritt, Melissa
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Aune, Dagfinn
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Terry, Kathryn
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Cramer, Daniel W ...
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Anderson, Karen ...
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