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A heterogeneous res...
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Otten, Julia,1973-Umeå universitet,Medicin
(författare)
A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes : a randomised controlled trial
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-04-26
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Springer,2018
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-150764
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150764URI
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https://doi.org/10.1007/s00125-018-4618-yDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Aims/hypothesis: The aim of the study was to investigate ectopic fat deposition and insulin sensitivity, in a parallel single-blinded randomised controlled trial, comparing Paleolithic diet alone with the combination of Paleolithic diet and exercise in individuals with type 2 diabetes. Methods: Thirty-two individuals with type 2 diabetes with BMI 25-40 kg/m(2) and 30-70 years of age followed a Paleolithic diet ad libitum for 12 weeks. In addition, study participants were randomised by computer program to either supervised combined exercise training (PD-EX group) or standard care exercise recommendations (PD group). Staff performing examinations and assessing outcomes were blinded to group assignment. Thirteen participants were analysed in each group: hepatic and peripheral insulin sensitivity were measured using the hyperinsulinaemic-euglycaemic clamp technique combined with [6,6-H-2(2)]glucose infusion, and liver fat was assessed by proton magnetic resonance spectroscopy; both analyses were secondary endpoints. Intramyocellular lipid (IMCL) content was measured by magnetic resonance spectroscopy as a secondary analysis. All examinations were performed at Umca University Hospital, Umca, Sweden. Results: Both study groups showed a median body weight loss of 7 kg. Fat mass decreased by 5.7 kg in the PD group and by 6.5 kg in the PD-EX group. Maximum oxygen uptake increased in the PD-EX group only. Liver fat showed a consistent reduction (74% decrease) in the PD group, while the response in the PD-EX group was heterogeneous (p < 0.05 for the difference between groups). IMCL content of the soleus muscle decreased by 40% in the PD group and by 22% in the PD-EX group (p < 0.05 for the difference between groups). Both groups improved their peripheral and adipose tissue insulin sensitivity, but not their hepatic insulin sensitivity. Plasma fetuin-A decreased by 11% in the PD group (p < 0.05) and remained unchanged in the PD-EX group. Liver fat changes during the intervention were correlated with changes in fetuin-A (r(S) = 0.63, p < 0.01). Participants did not report any important adverse events caused by the intervention. Conclusions/interpretation: A Paleolithic diet reduced liver fat and IMCL content, while there was a tissue-specific heterogeneous response to added exercise training.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Stomby, AndreasUmeå universitet,Medicin(Swepub:umu)ansa0059
(författare)
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Waling, MariaUmeå universitet,Institutionen för kostvetenskap(Swepub:umu)maawng02
(författare)
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Isaksson, AndreasUmeå universitet,Idrottsmedicin(Swepub:umu)anis0009
(författare)
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Söderström, IngegerdUmeå universitet,Medicin(Swepub:umu)inso0001
(författare)
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Ryberg, MatsUmeå universitet,Medicin(Swepub:umu)mary0013
(författare)
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Svensson, MichaelUmeå universitet,Idrottsmedicin(Swepub:umu)misv0002
(författare)
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Hauksson, JónUmeå universitet,Radiofysik(Swepub:umu)jonhan75
(författare)
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Olsson, TommyUmeå universitet,Medicin(Swepub:umu)tool0003
(författare)
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Umeå universitetMedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetologia: Springer61:7, s. 1548-15590012-186X1432-0428
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Otten, Julia, 19 ...
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Stomby, Andreas
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Waling, Maria
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Söderström, Inge ...
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Ryberg, Mats
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Svensson, Michae ...
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Hauksson, Jón
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Olsson, Tommy
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