Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

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Feitosa, Mary F.Washington University in St. Louis (author)

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Article/chapterEnglish2018

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2018-06-18
Public library science,2018
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-150780
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150780URI
https://doi.org/10.1371/journal.pone.0198166DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:138640792URI
https://lup.lub.lu.se/record/f6c9eb6b-d0a6-4524-be1b-172813823da1URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in approximate to 131 K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P <1.0 x 10(-5)). In Stage 2, these SNVs were tested for independent external replication in individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10(-8)). For African ancestry samples, we detected 18 potentially novel BP loci (P< 5.0 x 10(-8)) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2 have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.

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Kraja, Aldi T.Washington University in St. Louis (author)
Chasman, Daniel I.Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (author)
Sung, Yun J.Washington University in St. Louis (author)
Winkler, Thomas W.University of Regensburg (author)
Ntalla, IoannaQueen Mary University (author)
Guo, XiuqingUniversity of California, Los Angeles (author)
Franceschini, NoraUniversity of North Carolina (author)
Cheng, Ching-YuDuke–NUS Medical School,National University of Singapore,Singapore Eye Research Institute (author)
Sim, XuelingNational University Health System (author)
Vojinovic, DinaErasmus University Medical Center (author)
Marten, JonathanUniversity of Edinburgh (author)
Musani, Solomon K.University of Mississippi Medical Center (author)
Li, ChangweiUniversity of Georgia (author)
Bentley, Amy R.National Human Genome Research Institute (author)
Brown, Michael R.University of Texas (author)
Schwander, KarenWashington University in St. Louis (author)
Richard, Melissa A.University of Texas (author)
Noordam, RaymondLeiden University Medical Centre (author)
Aschard, HuguesHarvard University,Pasteur Institute (author)
Bartz, Traci M.University of Washington (author)
Bielak, Lawrence F.University of Michigan (author)
Dorajoo, RajkumarA*Star, Genome Institute of Singapore (GIS) (author)
Fisher, VirginiaBoston University (author)
Hartwig, Fernando P.University of Bristol,Federal University of Pelotas (author)
Horimoto, Andrea R. V. R.University of São Paulo (author)
Lohman, Kurt K.Wake Forest University (author)
Manning, Alisa K.Massachusetts General Hospital,Harvard Medical School (author)
Rankinen, TuomoPennington Biomedical Research Center (author)
Smith, Albert V.University of Iceland,Icelandic Heart Association (author)
Tajuddin, Salman M.National Institute on Aging, United States (author)
Wojczynski, Mary K.Washington University in St. Louis (author)
Alver, MarisUniversity of Tartu (author)
Boissel, MathildeUniversity of Lille (author)
Cai, QiuyinVanderbilt University (author)
Campbell, ArchieUniversity of Edinburgh (author)
Chai, Jin FangNational University Health System (author)
Chen, XuKarolinska Institute,Karolinska Institutet (author)
Divers, JasminWake Forest University (author)
Gao, ChuanWake Forest University,Washington University in St. Louis (author)
Goel, AnujUniversity of Oxford (author)
Hagemeijer, YanickUniversity Medical Center Groningen (author)
Harris, Sarah E.University of Edinburgh (author)
He, MeianHuazhong University of Science and Technology (author)
Hsu, Fang-ChiWake Forest University (author)
Jackson, Anne U.University of Michigan (author)
Kahonen, MikaUniversity of Tampere,Tampere University Hospital (author)
Kasturiratne, AnuradhaniUniversity of Kelaniya (author)
Komulainen, PirjoKarolinska Institutet (author)
Kuhnel, Brigitte (author)
Laguzzi, FedericaKarolinska Institutet (author)
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Varga, Tibor V.Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Genetic and Molecular Epidemiology,Skåne University Hospital(Swepub:lu)med-tv_ (author)
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Weiss, Stefan (author)
Franks, Paul W.Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Genetic and Molecular Epidemiology,Harvard University(Swepub:lu)med-plf (author)
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de Mutsert, Renee (author)
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Ehret, Georg (author)
Eppinga, Ruben N. (author)
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Friedlander, Yechiel (author)
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Ghanbari, Mohsen (author)
Gigante, BrunaKarolinska Institutet (author)
Gu, C. Charles (author)
Gu, Dongfeng (author)
Hagenaars, Saskia P. (author)
Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
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Kilpelainen, Tuomas O. (author)
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Mohlke, Karen L.Karolinska Institutet (author)
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Pedersen, Nancy L.Karolinska Institutet (author)
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Peyser, Patricia A. (author)
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Raffel, Leslie J. (author)
Raitakari, Olli T. (author)
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Kato, Norihiro (author)
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Laurie, Cathy C. (author)
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Lehtimaki, Terho (author)
Study, Lifelines Cohort (author)
Magnusson, Patrik K. E. (author)
Oldehinkel, Albertine J. (author)
Penninx, Brenda W. J. H. (author)
Poiasek, Ozren (author)
Porteous, David J. (author)
Rauramaa, Rainer (author)
Samani, Nilesh J. (author)
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Shu, Xiao-Ou (author)
van der Harst, Pim (author)
Wagenknecht, Lynne E. (author)
Wareham, Nicholas J. (author)
Watkins, Hugh (author)
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Wickremasinghe, Ananda R. (author)
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Christensen, Kaare (author)
Evans, Michele K. (author)
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Horta, Bernardo L. (author)
Kardia, Sharon L. R. (author)
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Pereira, Alexandre C. (author)
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Ridker, Paul M. (author)
van Dam, Rob M. (author)
Gauderman, W. James (author)
Zhu, Xiaofeng (author)
Mook-Kanamori, Dennis O. (author)
Fornage, Myriam (author)
Rotimi, Charles N. (author)
Cupples, L. Adrienne (author)
Kelly, Tanika N. (author)
Fox, Ervin R. (author)
Hayward, Caroline (author)
van Duijn, Cornelia M. (author)
Tai, E. Shyong (author)
Wong, Tien Yin (author)
Kooperberg, Charles (author)
Palmas, Walter (author)
Rice, KennethUniversity of Washington (author)
Morrison, Alanna C.University of Texas (author)
Elliott, PaulImperial College London (author)
Caulfield, Mark J.Queen Mary University (author)
Munroe, Patricia B.Queen Mary University (author)
Rao, Dabeeru C. (author)
Province, Michael A.Washington University in St. Louis (author)
Levy, DanielFramingham Heart Study,National Heart Lung and Blood Institute (author)
Washington University in St. LouisBrigham and Women's Hospital / Harvard Medical School (creator_code:org_t)

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By the author/editor: Feitosa, Mary F.; Kraja, Aldi T.; Chasman, Daniel ...; Sung, Yun J.; Winkler, Thomas ...; Ntalla, Ioanna; show more...; Guo, Xiuqing; Franceschini, No ...; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon ...; Li, Changwei; Bentley, Amy R.; Brown, Michael R ...; Schwander, Karen; Richard, Melissa ...; Noordam, Raymond; Aschard, Hugues; Bartz, Traci M.; Bielak, Lawrence ...; Dorajoo, Rajkuma ...; Fisher, Virginia; Hartwig, Fernand ...; Horimoto, Andrea ...; Lohman, Kurt K.; Manning, Alisa K ...; Rankinen, Tuomo; Smith, Albert V.; Tajuddin, Salman ...; Wojczynski, Mary ...; Alver, Maris; Boissel, Mathild ...; Cai, Qiuyin; Campbell, Archie; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Gao, Chuan; Goel, Anuj; Hagemeijer, Yani ...; Harris, Sarah E.; He, Meian; Hsu, Fang-Chi; Jackson, Anne U.; Kahonen, Mika; Kasturiratne, An ...; Komulainen, Pirj ...; Kuhnel, Brigitte; Laguzzi, Federic ...; Luan, Jian'an; Matoba, Nana; Nolte, Ilja M.; Padmanabhan, San ...; Riaz, Muhammad; Rueedi, Rico; Robino, Antoniet ...; Said, M. Abdulla ...; Scott, Robert A.; Sofer, Tamar; Stancakova, Alen ...; Takeuchi, Fumihi ...; Tayo, Bamidele O ...; van der Most, Pe ...; Varga, Tibor V.; Vitart, Veroniqu ...; Wang, Yajuan; Ware, Erin B.; Warren, Helen R.; Weiss, Stefan; Franks, Paul W.; Yanek, Lisa R.; Zhang, Weihua; Zhao, Jing Hua; Afaq, Saima; Amin, Najaf; Amini, Marzyeh; Arking, Dan E.; Aung, Tin; Boerwinkle, Eric; Borecki, Ingrid; Broeckel, Ulrich; Brown, Morris; Brumat, Marco; Burke, Gregory L ...; Canouil, Mickael; Chakravarti, Ara ...; Charumathi, Saba ...; Chen, Yii-Der Id ...; Connell, John M.; Correa, Adolfo; Fuentes, Lisa de ...; de Mutsert, Rene ...; de Silva, H. Jan ...; Deng, Xuan; Ding, Jingzhong; Duan, Qing; Eaton, Charles B ...; Ehret, Georg; Eppinga, Ruben N ...; Evangelou, Evang ...; Fau, Jessica D.; Felix, Stephan B ...; Forouhi, Nita G.; Forrester, Terre ...; Franco, Oscar H.; Friedlander, Yec ...; Gandin, Ilaria; Gao, He; Ghanbari, Mohsen; Gigante, Bruna; Gu, C. Charles; Gu, Dongfeng; Hagenaars, Saski ...; Hallmans, Göran, ...; Harris, Tamara B ...; He, Jiang; Heikkinen, Sami; Heng, Chew-Kiat; Hirata, Makoto; Howard, Barbara ...; Ikram, M. Arfan; John, Ulrich; Katsuya, Tomohir ...; Khor, Chiea Chue ...; Kilpelainen, Tuo ...; Koh, Woon-Puay; Krieger, Jose E.; Kritchevsky, Ste ...; Kubo, Michiaki; Kuusisto, Johann ...; Lakka, Timo A.; Langefeld, Carl ...; Langenberg, Clau ...; Launer, Lenore J ...; Lehne, Benjamin; Lewis, Cora E.; Li, Yize; Lin, Shiow; Liu, Jianjun; Liu, Jingmin; Loh, Marie; Louie, Tin; Magi, Reedik; McKenzie, Colin ...; Meitinger, Thoma ...; Metspalu, Andres; Milaneschi, Yuri; Milani, Lili; Mohlke, Karen L.; Momozawa, Yukihi ...; Nalls, Mike A.; Nelson, Christop ...; Sotoodehnia, Nel ...; Norris, Jill M.; O'Connell, Jeff ...; Palmer, Nicholet ...; Perls, Thomas; Pedersen, Nancy ...; Peters, Annette; Peyser, Patricia ...; Poulter, Neil; Raffel, Leslie J ...; Raitakari, Olli ...; Roll, Kathryn; Rose, Lynda M.; Rosendaal, Frits ...; Rotter, Jerome I ...; Schmidt, Carsten ...; Schreiner, Pamel ...; Schupf, Nicole; Scott, William R ...; Sever, Peter S.; Shi, Yuan; Sidney, Stephen; Sims, Mario; Sitlani, Colleen ...; Smith, Jennifer ...; Snieder, Harold; Starr, John M.; Strauch, Konstan ...; Stringham, Heath ...; Tan, Nicholas Y. ...; Tang, Hua; Taylor, Kent D.; Teo, Yik Ying; Tham, Yih Chung; Turner, Stephen ...; Uitterlinden, An ...; Vollenweider, Pe ...; Waldenberger, Me ...; Wang, Lihua; Wang, Ya Xing; Bin Wei, Wen; Williams, Christ ...; Yao, Jie; Yu, Caizheng; Yuan, Jian-Min; Zhao, Wei; Zonderman, Alan ...; Becker, Diane M.; Boehnke, Michael; Bowden, Donald W ...; Chambers, John C ...; Deary, Ian J.; Esko, Tonu; Farrall, Martin; Freedman, Barry ...; Froguel, Philipp ...; Gasparini, Paolo; Gieger, Christia ...; Jonas, Jost Brun ...; Kamatani, Yoichi ...; Kato, Norihiro; Kooner, Jaspal S ...; Kutalik, Zoltan; Laakso, Markku; Laurie, Cathy C.; Leander, Karin; Lehtimaki, Terho; Study, Lifelines ...; Magnusson, Patri ...; Oldehinkel, Albe ...; Penninx, Brenda ...; Poiasek, Ozren; Porteous, David ...; Rauramaa, Rainer; Samani, Nilesh J ...; Scott, James; Shu, Xiao-Ou; van der Harst, P ...; Wagenknecht, Lyn ...; Wareham, Nichola ...; Watkins, Hugh; Weir, David R.; Wickremasinghe, ...; Wu, Tangchun; Zheng, Wei; Bouchard, Claude; Christensen, Kaa ...; Evans, Michele K ...; Gudnason, Vilmun ...; Horta, Bernardo ...; Kardia, Sharon L ...; Liu, Yongmei; Pereira, Alexand ...; Psaty, Bruce M.; Ridker, Paul M.; van Dam, Rob M.; Gauderman, W. Ja ...; Zhu, Xiaofeng; Mook-Kanamori, D ...; Fornage, Myriam; Rotimi, Charles ...; Cupples, L. Adri ...; Kelly, Tanika N.; Fox, Ervin R.; Hayward, Carolin ...; van Duijn, Corne ...; Tai, E. Shyong; Wong, Tien Yin; Kooperberg, Char ...; Palmas, Walter; Rice, Kenneth; Morrison, Alanna ...; Elliott, Paul; Caulfield, Mark ...; Munroe, Patricia ...; Rao, Dabeeru C.; Province, Michae ...; Levy, Daniel; show less...

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