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  • Berggren, Daniel MorenoUppsala universitet,Hematologi (author)

Prognostic scoring systems for myelodysplastic syndromes (MDS) in a population-based setting : a report from the Swedish MDS register

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-04-29
  • Wiley,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-150884
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150884URI
  • https://doi.org/10.1111/bjh.15243DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67334URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138381440URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-149372URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-357712URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The myelodysplastic syndromes (MDS) have highly variable outcomes and prognostic scoring systems are important tools for risk assessment and to guide therapeutic decisions. However, few population-based studies have compared the value of the different scoring systems. With data from the nationwide Swedish population-based MDS register we validated the International Prognostic Scoring System (IPSS), revised IPSS (IPSS-R) and the World Health Organization (WHO) Classification-based Prognostic Scoring System (WPSS). We also present population-based data on incidence, clinical characteristics including detailed cytogenetics and outcome from the register. The study encompassed 1329 patients reported to the register between 2009 and 2013, 14% of these had therapy-related MDS (t-MDS). Based on the MDS register, the yearly crude incidence of MDS in Sweden was 2.9 per 100000 inhabitants. IPSS-R had a significantly better prognostic power than IPSS (P < 0001). There was a trend for better prognostic power of IPSS-R compared to WPSS (P=0.05) and for WPSS compared to IPSS (P=0.07). IPSS-R was superior to both IPSS and WPSS for patients aged <= 70years. Patients with t-MDS had a worse outcome compared to de novo MDS (d-MDS), however, the validity of the prognostic scoring systems was comparable for d-MDS and t-MDS. In conclusion, population-based studies are important to validate prognostic scores in a real-world' setting. In our nationwide cohort, the IPSS-R showed the best predictive power.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Folkvaljon, YasinUppsala universitet,Institutionen för kirurgiska vetenskaper (author)
  • Engvall, MarieUppsala universitet,Medicinsk genetik och genomik(Swepub:uu)masev498 (author)
  • Sundberg, JohanUppsala universitet,Hematologi (author)
  • Lambe, MatsUppsala universitet,Karolinska Institutet,Uppsala Univ Hosp, Sweden; Karolinska Inst, Sweden,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (author)
  • Antunovic, PetarLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linkoping Univ Hosp, Dept Haematol, Linkoping, Sweden(Swepub:liu)petan27 (author)
  • Garelius, HegeSection for Haematology and Coagulation, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sect Haematol & Coagulat, Dept Med, Gothenburg, Sweden (author)
  • Lorenz, FryderykUmeå universitet,Onkologi,Department of Medical Biosciences, Umeå University, Umeå, Sweden,Umea Univ, Dept Med Biosci, Umea, Sweden(Swepub:umu)frlo0008 (author)
  • Nilsson, LarsDepartment of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Dept Haematol Oncol & Radiat Phys, Lund, Sweden (author)
  • Rasmussen, Bengt,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ Hosp, Sch Med Sci, Orebro, Sweden(Swepub:oru)bgrn (author)
  • Lehmann, SörenUppsala universitet,Karolinska Institutet,Uppsala Univ, Sweden,Hematologi(Swepub:uu)sorle534 (author)
  • Hellström-Lindberg, EvaKarolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Haematol & Regenerat Med, Stockholm, Sweden (author)
  • Jädersten, MartinKarolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Haematol & Regenerat Med, Stockholm, Sweden (author)
  • Ejerblad, ElisabethUppsala universitet,Hematologi(Swepub:uu)eleje020 (author)
  • Uppsala universitetHematologi (creator_code:org_t)

Related titles

  • In:British Journal of Haematology: Wiley181:5, s. 614-6270007-10481365-2141

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