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Potentiation by L-c...
Potentiation by L-cysteine of the bactericidal effect of hydrogen peroxide in Escherichia coli
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- Berglin, Ewa, MD, PhD, 1955- (author)
- Umeå universitet,Oral mikrobiologi
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- Edlund, Maj-Britt K. (author)
- Umeå universitet,Oral mikrobiologi
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- Nyberg, Göran K. (author)
- Umeå universitet,Oral mikrobiologi
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- Carlsson, Jan (author)
- Umeå universitet,Oral mikrobiologi
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(creator_code:org_t)
- American Society for Microbiology, 1982
- 1982
- English.
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In: Journal of Bacteriology. - : American Society for Microbiology. - 0021-9193 .- 1098-5530. ; 152:1, s. 81-88
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Under anaerobic conditions an exponentially growing culture of Escherichia coli K-12 was exposed to hydrogen peroxide in the presence of various compounds. Hydrogen peroxide (0.1 mM) together with 0.1 mM L-cysteine or L-cystine killed the organisms more rapidly than 10 mM hydrogen peroxide alone. The exposure of E. coli to hydrogen peroxide in the presence of L-cysteine inhibited some of the catalase. This inhibition, however, could not fully explain the 100-fold increase in hydrogen peroxide sensitivity of the organism in the presence of L-cysteine. Of other compounds tested only some thiols potentiated the bactericidal effect of hydrogen peroxide. These thiols were effective, however, only at concentrations significantly higher than 0.1 mM. The effect of L-cysteine and L-cystine could be annihilated by the metal ion chelating agent 2,2'-bipyridyl. DNA breakage in E. coli K-12 was demonstrated under conditions where the organisms were killed by hydrogen peroxide.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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