Sökning: id:"swepub:oai:DiVA.org:umu-152204" >
Multidirectional Ac...
Multidirectional Activity Control of Cellular Processes by a Versatile Chemo-optogenetic Approach
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
-
2018-08-17
-
Wiley-VCH Verlagsgesellschaft,2018
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-152204
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152204URI
-
https://doi.org/10.1002/anie.201806976DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
The spatiotemporal dynamics of proteins or organelles plays a vital role in controlling diverse cellular processes. However, acute control of activity at distinct locations within a cell is challenging. A versatile multidirectional activity control (MAC) approach is presented, which employs a photoactivatable system that may be dimerized upon chemical inducement. The system comprises second-generation SLF*-TMP (S*T) and photocaged NvocTMP-Cl dimerizers; where, SLF*-TMP features a synthetic ligand of the FKBP(F36V) binding protein, Nvoc is a caging group, and TMP is the antibiotic trimethoprim. Two MAC strategies are demonstrated to spatiotemporally control cellular signaling and intracellular cargo transport. The novel platform enables tunable, reversible, and rapid control of activity at multiple compartments in living cells.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Venkatachalapathy, Muthukumaran
(författare)
-
Dehmelt, Leif
(författare)
-
Wu, Yao-WenUmeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)(Swepub:umu)yawu0006
(författare)
-
Umeå universitetKemiska institutionen
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Angewandte Chemie International Edition: Wiley-VCH Verlagsgesellschaft57:37, s. 11993-119971433-78511521-3773
Internetlänk
Hitta via bibliotek
Till lärosätets databas