Vitamin D Intervention and Bone: A Randomized Clinical Trial in Fair- and Dark-skinned Children at Northern Latitudes

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Åkeson, Pia KarlslandLund University,Lunds universitet,Preventiv pediatrik,Forskargrupper vid Lunds universitet,Preventive Paediatrics,Lund University Research Groups (author)

Vitamin D Intervention and Bone : A Randomized Clinical Trial in Fair- and Dark-skinned Children at Northern Latitudes

Article/chapterEnglish2018

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Lippincott Williams & Wilkins,2018
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LIBRIS-ID:oai:DiVA.org:umu-152216
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152216URI
https://doi.org/10.1097/MPG.0000000000002031DOI
https://lup.lub.lu.se/record/af7daa67-810d-47c0-a1cc-51d0b0863f53URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Objectives: The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter.Methods: In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n = 206) with fair and dark skin in Sweden (55 degrees N-63 degrees N) received daily vitamin D supplements of 25 mu g, 10 mu g, or placebo (2 mu g) during 3 winter months. We measured BMD and BMC for total body (TB), total body less head (TBLH), femoral neck (FN), and spine at baseline and 4 months later. Intake of vitamin D and calcium, serum 25-hydroxy vitamin D (S-25 [OH]D), and related parameters were analyzed.Results: Despite lower S-25(OH)D in dark than fair-skinned children, BMD of TB (P = 0.012) and TBLH (P = 0.002) and BMC of TBLH (P = 0.04) were higher at baseline and follow-up in those with dark skin. Delta (Delta) BMD and BMC of TB and TBLH did not differ between intervention and placebo groups, but FN-BMC increased more among dark-skinned children in the 25 mu g (P = 0.038) and 10 mu g (P = 0.027) groups compared to placebo. We found no associations between Delta S-25(OH)D, P-parathyroid hormone, P-alkaline phosphatase, and Delta BMD and BMC, respectively.Conclusions: BMD and BMC remained higher in dark- than fair-skinned children despite lower vitamin D status. Even though no difference in general was found in BMD or BMC after vitamin D intervention, the increase in FN-BMC in dark-skinned children may suggest an influence on bone in those with initially insufficient vitamin D status.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
bone mineral content
bone mineral density
child
25-hydroxyvitamin D
skin color
25-hydroxyvitamin D
Bone mineral content
Bone mineral density
Child
Skin color

Added entries (persons, corporate bodies, meetings, titles ...)

Åkesson, Kristina E.Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-kak (author)
Lind, Torbjörn,1966-Umeå University,Umeå universitet,Pediatrik(Swepub:umu)toli0008 (author)
Hernell, OlleUmeå University,Umeå universitet,Pediatrik(Swepub:umu)olhe0002 (author)
Silfverdal, Sven-ArneUmeå University,Umeå universitet,Pediatrik(Swepub:umu)svar0002 (author)
Öhlund, Inger,1954-Umeå University,Umeå universitet,Pediatrik(Swepub:umu)inrlid73 (author)
Preventiv pediatrikForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Journal of Pediatric Gastroenterology and Nutrition - JPGN: Lippincott Williams & Wilkins67:3, s. 388-3940277-21161536-4801

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