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Cross-sectional rel...
Cross-sectional relationship between haemoglobin concentration and measures of physical and cognitive function in an older rural South African population
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Payne, Collin F. (author)
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Davies, Justine I. (author)
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Gomez-Olive, F. Xavier (author)
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Hands, Katherine J. (author)
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- Kahn, Kathleen (author)
- Umeå universitet,Epidemiologi och global hälsa,Medical Research Council/Wits University Rural Public Health and Health Transitions Research Unit, Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network, Accra, Ghana
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Kobayashi, Lindsay C. (author)
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Tipping, Brent (author)
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- Tollman, Stephen M. (author)
- Umeå universitet,Epidemiologi och global hälsa,Medical Research Council/Wits University Rural Public Health and Health Transitions Research Unit, Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa; INDEPTH Network, Accra, Ghana
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Wade, Alisha (author)
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Witham, Miles D. (author)
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(creator_code:org_t)
- 2018-04-21
- 2018
- English.
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In: Journal of Epidemiology and Community Health. - : BMJ Publishing Group Ltd. - 0143-005X .- 1470-2738. ; 72:9, s. 796-802
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Abstract
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- Background: Age cohort differences in haemoglobin concentrations and associations with physical and cognitive performance among populations of lower income and middle-income countries have not previously been described. We examined the association between these factors among older men and women in rural South Africa.Methods: We analysed cross-sectional data from a population-based study of rural South African men and women aged 40 and over (n=4499), with data drawn from questionnaire responses, a cognitive battery, objective physical function tests and blood tests. Anaemia was defined as a haemoglobin concentration <12 g/dL for women and <13 g/dL for men. We related haemoglobin concentrations to each of age, grip strength, walk speed and a latent cognitive function z-score for men and women separately. We used unadjusted correlations and linear models to adjust for comorbidities and inflammation.Results: In total, 1042 (43.0%) women and 833 (40.1%) men were anaemic. Haemoglobin concentrations were inversely correlated with age for men but not for women; in adjusted analyses, haemoglobin was 0.3 g/dL lower per decade older for men (95% CI 0.2 to 0.4 g/dL). In adjusted analyses, haemoglobin concentration was independently associated with grip strength in women (B=0.391, 95% CI 0.177 to 0.605), but this did not reach significance in men (B=0.266, 95% CI -0.019 to 0.552); no associations were observed between haemoglobin levels and walk speed or cognitive score.Conclusions: Anaemia was prevalent in this study population of middle-aged and older, rural South African adults, but in contrast to high-income countries, it was not associated with poor physical or cognitive function. Our findings need to be replicated in other populations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Payne, Collin F.
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Davies, Justine ...
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Gomez-Olive, F. ...
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Hands, Katherine ...
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Kahn, Kathleen
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Kobayashi, Linds ...
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show more...
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Tipping, Brent
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Tollman, Stephen ...
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Wade, Alisha
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Witham, Miles D.
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Umeå University