Neocortical neurogenesis in humans is restricted to development.

• Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of (14)C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally.

Nyckelord

Aged

Aged

80 and over

Aging

physiology

Animals

Antimetabolites

metabolism

Atmosphere

Autopsy

Bromodeoxyuridine

metabolism

Carbon Radioisotopes

metabolism

Humans

Middle Aged

Neocortex

cytology

embryology

growth & development

Nuclear Warfare

Stem Cells

cytology

physiology

Time Factors

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ref (ämneskategori)

art (ämneskategori)